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10.1128/AAC.04431-14 http://scihub22266oqcxt.onion/10.1128/AAC.04431-14 C4325779!4325779 !25534734     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25534734 &cmd=llinks): Failed to open stream: HTTP request failed! 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Sialic acid-binding protein Sp2CBMTD protects mice against lethal challenge with emerging influenza A (H7N9) virus |pdf=|usr=}}{{25534734 }} gab.com Text Sialic acid-binding protein Sp2CBMTD protects mice against lethal challenge with emerging influenza A (H7N9) virus JO: Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=25534734 #FOAvip Compounds that target the cellular factors essential for influenza virus replication represent an innovative approach to antiviral therapy. Sp2CBMTD is a genetically engineered multivalent protein that masks sialic acid-containing cellular receptors on the respiratory epithelium, which are recognized by influenza viruses. Here, we evaluated the antiviral potential of Sp2CBMTD against lethal infection in mice with an emerging A/Anhui/1/2013 (H7N9) influenza virus and addressed the mechanistic basis of its activity in vivo. Sp2CBMTD was administered to mice intranasally as a single or repeated dose (0.1, 1, 10, or 100 ?g) before (day -7, -3, and/or -1) or after (6 or 24 h) H7N9 virus inoculation. A single Sp2CBMTD dose (10 or 100 ?g) protected 80% to 100% of the mice when administered 7 days before the H7N9 lethal challenge. Repeated Sp2CBMTD administration conferred the highest protection, resulting in 100% survival of the mice even at the lowest dose tested (0.1 ?g). When treatment began 24 h after exposure to the H7N9 virus, a single administration of 100 ?g of Sp2CBMTD protected 40% of the mice from death. The administration of Sp2CBMTD induced the pulmonary expression of proinflammatory mediators (interleukin-6 [IL-6], IL-1?, RANTES, monocyte chemotactic protein-1 [MCP-1], macrophage inflammatory protein-1? [MIP-1?], and inducible protein [IP-10]) and recruited neutrophils to the respiratory tract before H7N9 virus infection, which resulted in less pronounced inflammation and rapid virus clearance from mouse lungs. Sp2CBMTD administration did not affect the virus-specific adaptive immune response, which was sufficient to protect against reinfection with a higher dose of homologous H7N9 virus or heterologous H5N1 virus. Thus, Sp2CBMTD was effective in preventing H7N9 infections in a lethal mouse model and holds promise as a prophylaxis option against zoonotic influenza viruses. Twit Text FOAVip Sialic acid-binding protein Sp2CBMTD protects mice against lethal challenge with emerging influenza A (H7N9) virus ????Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=25534734 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25534734 #FOAvip English Wikipedia <ref>{{Cite pmid|25534734 }}</ref> Sialic acid-binding protein Sp2CBMTD protects mice against lethal challenge with emerging influenza A (H7N9) virus #MMPMID25534734 Govorkova EA ; Baranovich T ; Marathe BM ; Yang L ; Taylor MA ; Webster RG ; Taylor GL ; Connaris H Antimicrob Agents Chemother 2015[Mar]; 59 (3 ): 1495-504 PMID25534734 show ga Compounds that target the cellular factors essential for influenza virus replication represent an innovative approach to antiviral therapy. Sp2CBMTD is a genetically engineered multivalent protein that masks sialic acid-containing cellular receptors on the respiratory epithelium, which are recognized by influenza viruses. Here, we evaluated the antiviral potential of Sp2CBMTD against lethal infection in mice with an emerging A/Anhui/1/2013 (H7N9) influenza virus and addressed the mechanistic basis of its activity in vivo. Sp2CBMTD was administered to mice intranasally as a single or repeated dose (0.1, 1, 10, or 100 ?g) before (day -7, -3, and/or -1) or after (6 or 24 h) H7N9 virus inoculation. A single Sp2CBMTD dose (10 or 100 ?g) protected 80% to 100% of the mice when administered 7 days before the H7N9 lethal challenge. Repeated Sp2CBMTD administration conferred the highest protection, resulting in 100% survival of the mice even at the lowest dose tested (0.1 ?g). When treatment began 24 h after exposure to the H7N9 virus, a single administration of 100 ?g of Sp2CBMTD protected 40% of the mice from death. The administration of Sp2CBMTD induced the pulmonary expression of proinflammatory mediators (interleukin-6 [IL-6], IL-1?, RANTES, monocyte chemotactic protein-1 [MCP-1], macrophage inflammatory protein-1? [MIP-1?], and inducible protein [IP-10]) and recruited neutrophils to the respiratory tract before H7N9 virus infection, which resulted in less pronounced inflammation and rapid virus clearance from mouse lungs. Sp2CBMTD administration did not affect the virus-specific adaptive immune response, which was sufficient to protect against reinfection with a higher dose of homologous H7N9 virus or heterologous H5N1 virus. Thus, Sp2CBMTD was effective in preventing H7N9 infections in a lethal mouse model and holds promise as a prophylaxis option against zoonotic influenza viruses. |*Influenza A Virus, H7N9 Subtype [MESH] |Animals [MESH] |Antiviral Agents/*therapeutic use [MESH] |Carrier Proteins/*therapeutic use [MESH] |Chemokines/biosynthesis [MESH] |Cytokines/biosynthesis [MESH] |Female [MESH] |Lung/immunology/virology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Orthomyxoviridae Infections/*drug therapy/immunology [MESH] |Receptors, Cell Surface/*physiology [MESH] |Sialic Acids/*metabolism [MESH]Sialic acid-binding protein Sp2CBMTD protects mice against lethal chal(epmc).pdf DeepDyve Pubget Overpricing