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10.1128/AAC.04808-14 http://scihub22266oqcxt.onion/10.1128/AAC.04808-14 C4325763!4325763 !25561334     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25561334 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25561334 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Antimicrob+Agents+Chemother 2015 ; 59 (3 ): 1680-9 Nephropedia Template TP {{tp|p=25561334 |t=2015. Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii |pdf=|usr=}}{{25561334 }} gab.com Text Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii JO: Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=25561334 #FOAvip Sulbactam is a class A ?-lactamase inhibitor with intrinsic whole-cell activity against certain bacterial species, including Acinetobacter baumannii. The clinical use of sulbactam for A. baumannii infections is of interest due to increasing multidrug resistance in this pathogen. However, the molecular drivers of its antibacterial activity and resistance determinants have yet to be precisely defined. Here we show that the antibacterial activities of sulbactam vary widely across contemporary A. baumannii clinical isolates and are mediated through inhibition of the penicillin-binding proteins (PBPs) PBP1 and PBP3, with very low frequency of resistance; the rare pbp3 mutants with high levels of resistance to sulbactam are attenuated in fitness. These results support further investigation of the potential clinical utility of sulbactam. Twit Text FOAVip Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii ????Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=25561334 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25561334 #FOAvip English Wikipedia <ref>{{Cite pmid|25561334 }}</ref> Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii #MMPMID25561334 Penwell WF ; Shapiro AB ; Giacobbe RA ; Gu RF ; Gao N ; Thresher J ; McLaughlin RE ; Huband MD ; DeJonge BL ; Ehmann DE ; Miller AA Antimicrob Agents Chemother 2015[Mar]; 59 (3 ): 1680-9 PMID25561334 show ga Sulbactam is a class A ?-lactamase inhibitor with intrinsic whole-cell activity against certain bacterial species, including Acinetobacter baumannii. The clinical use of sulbactam for A. baumannii infections is of interest due to increasing multidrug resistance in this pathogen. However, the molecular drivers of its antibacterial activity and resistance determinants have yet to be precisely defined. Here we show that the antibacterial activities of sulbactam vary widely across contemporary A. baumannii clinical isolates and are mediated through inhibition of the penicillin-binding proteins (PBPs) PBP1 and PBP3, with very low frequency of resistance; the rare pbp3 mutants with high levels of resistance to sulbactam are attenuated in fitness. These results support further investigation of the potential clinical utility of sulbactam. |Acinetobacter baumannii/*drug effects [MESH] |Anti-Bacterial Agents/*pharmacology [MESH] |Drug Resistance, Multiple, Bacterial/*physiology [MESH] |Penicillin-Binding Proteins/antagonists & inhibitors [MESH]Molecular mechanisms of sulbactam antibacterial activity and resistanc(epmc).pdf DeepDyve Pubget Overpricing