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10.1128/JVI.02744-14 http://scihub22266oqcxt.onion/10.1128/JVI.02744-14 C4325746!4325746!25428874     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Virol 2015 ; 89 (5): 2462-8 Nephropedia Template TP {{tp|p=25428874|t=2015. Interferon-Induced Ifit Proteins: Their Role in Viral Pathogenesis |pdf=|usr=}}{{25428874}} gab.com Text Interferon-Induced Ifit Proteins: Their Role in Viral Pathogenesis JO: J Virol http://www.kidney.de/pget.php?&tw=1&pmid=25428874 #FOAvip A major component of the protective antiviral host defense is contributed by the intracellular actions of the proteins encoded by interferon-stimulated genes (ISGs); among these are the interferon-induced proteins with tetratricopeptide repeats (IFITs), consisting of four members in human and three in mouse. IFIT proteins do not have any known enzyme activity. Instead, they inhibit virus replication by binding and regulating the functions of cellular and viral proteins and RNAs. Although all IFITs are comprised of multiple copies of the degenerate tetratricopeptide repeats, their distinct tertiary structures enable them to bind different partners and affect host-virus interactions differently. The recent use of Ifit knockout mouse models has revealed novel antiviral functions of these proteins and new insights into the specificities of ISG actions. This article focuses on human and murine IFIT1 and IFIT2 by reviewing their mechanisms of action, their critical roles in protecting mice from viral pathogenesis, and viral strategies to evade IFIT action. Twit Text FOAVip Interferon-Induced Ifit Proteins: Their Role in Viral Pathogenesis ????J Virol http://www.kidney.de/pget.php?&tw=1&pmid=25428874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25428874 #FOAvip English Wikipedia <ref>{{Cite pmid|25428874}}</ref> Interferon-Induced Ifit Proteins: Their Role in Viral Pathogenesis #MMPMID25428874 Fensterl V; Sen GC J Virol 2015[Mar]; 89 (5): 2462-8 PMID25428874show ga A major component of the protective antiviral host defense is contributed by the intracellular actions of the proteins encoded by interferon-stimulated genes (ISGs); among these are the interferon-induced proteins with tetratricopeptide repeats (IFITs), consisting of four members in human and three in mouse. IFIT proteins do not have any known enzyme activity. Instead, they inhibit virus replication by binding and regulating the functions of cellular and viral proteins and RNAs. Although all IFITs are comprised of multiple copies of the degenerate tetratricopeptide repeats, their distinct tertiary structures enable them to bind different partners and affect host-virus interactions differently. The recent use of Ifit knockout mouse models has revealed novel antiviral functions of these proteins and new insights into the specificities of ISG actions. This article focuses on human and murine IFIT1 and IFIT2 by reviewing their mechanisms of action, their critical roles in protecting mice from viral pathogenesis, and viral strategies to evade IFIT action. äInterferon-Induced Ifit Proteins: Their Role in Viral Pathogenesis (epmc).pdf DeepDyve Pubget Overpricing