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10.1016/j.immuni.2014.09.007 http://scihub22266oqcxt.onion/10.1016/j.immuni.2014.09.007 C4324721!4324721 !25308332     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25308332 &cmd=llinks): Failed to open stream: HTTP request failed! 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CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection |pdf=|usr=}}{{25308332 }} gab.com Text CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25308332 #FOAvip Tissue-resident memory T (Trm) cells provide enhanced protection against infection at mucosal sites. Here we found that CD4(+) T cells are important for the formation of functional lung-resident CD8(+) T cells after influenza virus infection. In the absence of CD4(+) T cells, CD8(+) T cells displayed reduced expression of CD103 (Itgae), were mislocalized away from airway epithelia, and demonstrated an impaired ability to recruit CD8(+) T cells to the lung airways upon heterosubtypic challenge. CD4(+) T cell-derived interferon-? was necessary for generating lung-resident CD103(+) CD8(+) Trm cells. Furthermore, expression of the transcription factor T-bet was increased in "unhelped" lung Trm cells, and a reduction in T-bet rescued CD103 expression in the absence of CD4(+) T cell help. Thus, CD4(+) T cell-dependent signals are important to limit expression of T-bet and allow for the development of CD103(+) CD8(+) Trm cells in the lung airways following respiratory infection. Twit Text FOAVip CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25308332 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25308332 #FOAvip English Wikipedia <ref>{{Cite pmid|25308332 }}</ref> CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection #MMPMID25308332 Laidlaw BJ ; Zhang N ; Marshall HD ; Staron MM ; Guan T ; Hu Y ; Cauley LS ; Craft J ; Kaech SM Immunity 2014[Oct]; 41 (4 ): 633-45 PMID25308332 show ga Tissue-resident memory T (Trm) cells provide enhanced protection against infection at mucosal sites. Here we found that CD4(+) T cells are important for the formation of functional lung-resident CD8(+) T cells after influenza virus infection. In the absence of CD4(+) T cells, CD8(+) T cells displayed reduced expression of CD103 (Itgae), were mislocalized away from airway epithelia, and demonstrated an impaired ability to recruit CD8(+) T cells to the lung airways upon heterosubtypic challenge. CD4(+) T cell-derived interferon-? was necessary for generating lung-resident CD103(+) CD8(+) Trm cells. Furthermore, expression of the transcription factor T-bet was increased in "unhelped" lung Trm cells, and a reduction in T-bet rescued CD103 expression in the absence of CD4(+) T cell help. Thus, CD4(+) T cell-dependent signals are important to limit expression of T-bet and allow for the development of CD103(+) CD8(+) Trm cells in the lung airways following respiratory infection. |*Immunologic Memory [MESH] |Animals [MESH] |Antigens, CD/immunology [MESH] |CD4-Positive T-Lymphocytes/*immunology [MESH] |CD8-Positive T-Lymphocytes/*immunology [MESH] |Influenza A Virus, H3N2 Subtype/*immunology [MESH] |Integrin alpha Chains/immunology [MESH] |Interferon-gamma/immunology [MESH] |Lung/cytology/*immunology [MESH] |Lymphocyte Activation/immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mucous Membrane/cytology/immunology [MESH] |Orthomyxoviridae Infections/*immunology [MESH] |T-Box Domain Proteins/*biosynthesis [MESH]CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ (epmc).pdf DeepDyve Pubget Overpricing