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10.1016/j.pharmthera.2014.11.008 http://scihub22266oqcxt.onion/10.1016/j.pharmthera.2014.11.008 C4324083!4324083!25448040     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharmacol+Ther 2015 ; ä (ä): 123-35 Nephropedia Template TP {{tp|p=25448040|t=2015. Leukocyte integrins: Role in leukocyte recruitment and as therapeutic targets in inflammatory disease |pdf=|usr=}}{{25448040}} gab.com Text Leukocyte integrins: Role in leukocyte recruitment and as therapeutic targets in inflammatory disease JO: Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=25448040 #FOAvip Infection or sterile inflammation triggers site-specific attraction of leukocytes. Leukocyte recruitment is a process comprising several steps orchestrated by adhesion molecules, chemokines, cytokines and endogenous regulatory molecules. Distinct adhesive interactions between endothelial cells and leukocytes and signalling mechanisms contribute to the temporal and spatial fine-tuning of the leukocyte adhesion cascade. Central players in the leukocyte adhesion cascade include the leukocyte adhesion receptors of the ?2-integrin family, such as the ?L?2 and ?M?2 integrins, or of the ?1-integrin family, such as the ?4?1- integrin. Given the central involvement of leukocyte recruitment in different inflammatory and autoimmune diseases, the leukocyte adhesion cascade in general, and leukocyte integrins in particular, represent key therapeutic targets. In this context, the present review focuses on the role of leukocyte integrins in the leukocyte adhesion cascade. Experimental evidence that has implicated leukocyte integrins as targets in animal models of inflammatory disorders, such as experimental autoimmune encephalomyelitis, psoriasis, inflammatory bone loss and inflammatory bowel disease as well as preclinical and clinical therapeutic applications of antibodies that target leukocyte integrins in various inflammatory disorders are presented. Finally, we review recent findings on endogenous inhibitors that modify leukocyte integrin function, which could emerge as promising therapeutic targets. Twit Text FOAVip Leukocyte integrins: Role in leukocyte recruitment and as therapeutic targets in inflammatory disease ????Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=25448040 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25448040 #FOAvip English Wikipedia <ref>{{Cite pmid|25448040}}</ref> Leukocyte integrins: Role in leukocyte recruitment and as therapeutic targets in inflammatory disease #MMPMID25448040 Mitroulis I; Alexaki VI; Kourtzelis I; Ziogas A; Hajishengallis G; Chavakis T Pharmacol Ther 2015[Mar]; ä (ä): 123-35 PMID25448040show ga Infection or sterile inflammation triggers site-specific attraction of leukocytes. Leukocyte recruitment is a process comprising several steps orchestrated by adhesion molecules, chemokines, cytokines and endogenous regulatory molecules. Distinct adhesive interactions between endothelial cells and leukocytes and signalling mechanisms contribute to the temporal and spatial fine-tuning of the leukocyte adhesion cascade. Central players in the leukocyte adhesion cascade include the leukocyte adhesion receptors of the ?2-integrin family, such as the ?L?2 and ?M?2 integrins, or of the ?1-integrin family, such as the ?4?1- integrin. Given the central involvement of leukocyte recruitment in different inflammatory and autoimmune diseases, the leukocyte adhesion cascade in general, and leukocyte integrins in particular, represent key therapeutic targets. In this context, the present review focuses on the role of leukocyte integrins in the leukocyte adhesion cascade. Experimental evidence that has implicated leukocyte integrins as targets in animal models of inflammatory disorders, such as experimental autoimmune encephalomyelitis, psoriasis, inflammatory bone loss and inflammatory bowel disease as well as preclinical and clinical therapeutic applications of antibodies that target leukocyte integrins in various inflammatory disorders are presented. Finally, we review recent findings on endogenous inhibitors that modify leukocyte integrin function, which could emerge as promising therapeutic targets. äLeukocyte integrins: Role in leukocyte recruitment and as therapeutic (epmc).pdf DeepDyve Pubget Overpricing