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10.1007/s00018-014-1732-y http://scihub22266oqcxt.onion/10.1007/s00018-014-1732-y C4323860!4323860!25216704     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Life+Sci 2015 ; 72 (5): 999-1008 Nephropedia Template TP {{tp|p=25216704|t=2015. The cellular origin of laminin determines its role in blood pressure regulation |pdf=|usr=}}{{25216704}} gab.com Text The cellular origin of laminin determines its role in blood pressure regulation JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=25216704 #FOAvip Laminin of different cellular source has distinct functions. In addition to vascular smooth muscle cells (SMCs), aorta also contains a small population of nestin+ cells, whose function remains unknown. This study investigates the role of SMC- and nestin+ cell-derived laminin in blood pressure (BP) regulation and SMC contractibility. Using mice with laminin deficiency in SMCs (SKO) or nestin+ cells (NKO), we examined laminin-dependent changes in baseline BP. Contractile protein expression was reduced in SKO but not NKO mice, consistent with their respectively low and normal baseline BP measurements. At the ultrastructural level, SKO SMCs maintained the contractile phenotype with reduced elasticity, whereas NKO SMCs switched to the synthetic phenotype and showed degeneration. Additionally, angiotensin II (Ang II) significantly increased BP in SKO but not NKO mice. It also enhanced contractile proteins to the same levels and induced SMC degeneration in both knockout mice. These data suggest that SMC laminin regulates BP via modulating contractile protein expression, whereas nestin+ cell-derived laminin contributes to SMC phenotypic switch. Twit Text FOAVip The cellular origin of laminin determines its role in blood pressure regulation ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=25216704 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25216704 #FOAvip English Wikipedia <ref>{{Cite pmid|25216704}}</ref> The cellular origin of laminin determines its role in blood pressure regulation #MMPMID25216704 Yao Y; Norris EH; Strickland S Cell Mol Life Sci 2015[Mar]; 72 (5): 999-1008 PMID25216704show ga Laminin of different cellular source has distinct functions. In addition to vascular smooth muscle cells (SMCs), aorta also contains a small population of nestin+ cells, whose function remains unknown. This study investigates the role of SMC- and nestin+ cell-derived laminin in blood pressure (BP) regulation and SMC contractibility. Using mice with laminin deficiency in SMCs (SKO) or nestin+ cells (NKO), we examined laminin-dependent changes in baseline BP. Contractile protein expression was reduced in SKO but not NKO mice, consistent with their respectively low and normal baseline BP measurements. At the ultrastructural level, SKO SMCs maintained the contractile phenotype with reduced elasticity, whereas NKO SMCs switched to the synthetic phenotype and showed degeneration. Additionally, angiotensin II (Ang II) significantly increased BP in SKO but not NKO mice. It also enhanced contractile proteins to the same levels and induced SMC degeneration in both knockout mice. These data suggest that SMC laminin regulates BP via modulating contractile protein expression, whereas nestin+ cell-derived laminin contributes to SMC phenotypic switch. äThe cellular origin of laminin determines its role in blood pressure r(epmc).pdf DeepDyve Pubget Overpricing