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10.1016/j.jsbmb.2014.11.002

http://scihub22266oqcxt.onion/10.1016/j.jsbmb.2014.11.002
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C4323845!4323845!25448737
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suck abstract from ncbi


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pmid25448737      J+Steroid+Biochem+Mol+Biol 2015 ; ä (ä): 81-4
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  • Membrane-mediated Actions of 1,25-Dihydroxy Vitamin D3: A Review of the Roles of Phospholipase A2 Activating Protein and Ca2+/Calmodulin-dependent Protein Kinase II #MMPMID25448737
  • Doroudi M; Schwartz Z; Boyan BD
  • J Steroid Biochem Mol Biol 2015[Mar]; ä (ä): 81-4 PMID25448737show ga
  • The secosteroid 1?,25-dihydroxy vitamin D3 [1?,25(OH)2D3] acts on cells via classical steroid hormone receptor-mediated gene transcription and by initiating rapid membrane-mediated signaling pathways. In its membrane-initiated pathway, after 1?,25(OH)2D3 interacts with protein disulfide isomerase, family A, member 3 (Pdia3) in caveolae, phospholipase A2 (PLA2) and protein kinase C (PKC) are activated. Recent efforts to determine the signaling proteins involved in the 1?,25(OH)2D3 signal from Pdia3 to PLA2 have indicated that phospholipase A2 activating protein (PLAA) and Ca2+/calmodulin-dependent kinase II (CaMKII) are required. PLAA is located in caveolae, where it interacts with Pdia3 and caveolin-1 (Cav-1) to initiate rapid signaling via CaMKII, activating PLA2, leading to activation of protein kinase C (PKC) and PKC-dependent responses.
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