Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.4049/jimmunol.1400336 http://scihub22266oqcxt.onion/10.4049/jimmunol.1400336 C4321875!4321875!25392527     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2014 ; 193 (12): 5904-13 Nephropedia Template TP {{tp|p=25392527|t=2014. A novel mechanism of B-cell mediated immune suppression through CD73-expression and adenosine production |pdf=|usr=}}{{25392527}} gab.com Text A novel mechanism of B-cell mediated immune suppression through CD73-expression and adenosine production JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25392527 #FOAvip Immune suppression by regulatory T (Treg) cells and regulatory B (Breg) cells is a critical mechanism to limit excess inflammation and autoimmunity. IL-10 is considered to be the major mediator of B cell-induced immune suppression. Here, we report a novel mechanism for immune suppression through adenosine generation by B cells. We identified a novel population of B cells that expresses CD73 as well as CD39, two ecto-enzymes that together catalyze the extracellular dephosphorylation of adenine nucleotides to adenosine. Whereas CD39 expression is common among B cells, CD73 expression is not. Approximately 30?50% of B-1 cells (B220+CD23?) and IL-10 producing B (B10) cells (B220+CD5+CD1dhi) are CD73hi, depending on mouse strain, whereas few conventional B-2 cells (B220+CD23+AA4.1?) express CD73. In keeping with expression of both CD73 and CD39, we found that CD73+ B cells produce adenosine in the presence of substrate whereas B-2 cells don?t. CD73?/? mice were more susceptible to dextran sulfate sodium salt (DSS)-induced colitis than wild type (WT) mice, and transfer of CD73+ B cells ameliorated the severity of colitis, suggesting that B cell CD73/CD39/adenosine can modulate DSS-induced colitis. IL-10 production by B cells is not affected by CD73-deficiency. Interestingly, adenosine generation by IL-10?/? B cells is impaired due to reduced expression of CD73, indicating an unexpected connection between IL-10 and adenosine and suggesting caution in interpreting the results of studies with IL-10?/? cells. Together our findings demonstrate a novel regulatory role of B cells on colitis through adenosine generation in an IL-10-independent manner. Twit Text FOAVip A novel mechanism of B-cell mediated immune suppression through CD73-expression and adenosine production ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25392527 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25392527 #FOAvip English Wikipedia <ref>{{Cite pmid|25392527}}</ref> A novel mechanism of B-cell mediated immune suppression through CD73-expression and adenosine production #MMPMID25392527 Kaku H; Cheng KF; Al-Abed Y; Rothstein TL J Immunol 2014[Dec]; 193 (12): 5904-13 PMID25392527show ga Immune suppression by regulatory T (Treg) cells and regulatory B (Breg) cells is a critical mechanism to limit excess inflammation and autoimmunity. IL-10 is considered to be the major mediator of B cell-induced immune suppression. Here, we report a novel mechanism for immune suppression through adenosine generation by B cells. We identified a novel population of B cells that expresses CD73 as well as CD39, two ecto-enzymes that together catalyze the extracellular dephosphorylation of adenine nucleotides to adenosine. Whereas CD39 expression is common among B cells, CD73 expression is not. Approximately 30?50% of B-1 cells (B220+CD23?) and IL-10 producing B (B10) cells (B220+CD5+CD1dhi) are CD73hi, depending on mouse strain, whereas few conventional B-2 cells (B220+CD23+AA4.1?) express CD73. In keeping with expression of both CD73 and CD39, we found that CD73+ B cells produce adenosine in the presence of substrate whereas B-2 cells don?t. CD73?/? mice were more susceptible to dextran sulfate sodium salt (DSS)-induced colitis than wild type (WT) mice, and transfer of CD73+ B cells ameliorated the severity of colitis, suggesting that B cell CD73/CD39/adenosine can modulate DSS-induced colitis. IL-10 production by B cells is not affected by CD73-deficiency. Interestingly, adenosine generation by IL-10?/? B cells is impaired due to reduced expression of CD73, indicating an unexpected connection between IL-10 and adenosine and suggesting caution in interpreting the results of studies with IL-10?/? cells. Together our findings demonstrate a novel regulatory role of B cells on colitis through adenosine generation in an IL-10-independent manner. äA novel mechanism of B-cell mediated immune suppression through CD73-e(epmc).pdf DeepDyve Pubget Overpricing