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10.1016/j.molcel.2014.08.026 http://scihub22266oqcxt.onion/10.1016/j.molcel.2014.08.026 C4319980!4319980 !25263596     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25263596 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2014 ; 56 (2 ): 286-297 Nephropedia Template TP {{tp|p=25263596 |t=2014. 5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation |pdf=|usr=}}{{25263596 }} gab.com Text 5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25263596 #FOAvip In mammals, cytosine methylation (5mC) is widely distributed throughout the genome but is notably depleted from active promoters and enhancers. While the role of DNA methylation in promoter silencing has been well documented, the function of this epigenetic mark at enhancers remains unclear. Recent experiments have demonstrated that enhancers are enriched for 5-hydroxymethylcytosine (5hmC), an oxidization product of the Tet family of 5mC dioxygenases and an intermediate of DNA demethylation. These results support the involvement of Tet proteins in the regulation of dynamic DNA methylation at enhancers. By mapping DNA methylation and hydroxymethylation at base resolution, we find that deletion of Tet2 causes extensive loss of 5hmC at enhancers, accompanied by enhancer hypermethylation, reduction of enhancer activity, and delayed gene induction in the early steps of differentiation. Our results reveal that DNA demethylation modulates enhancer activity, and its disruption influences the timing of transcriptome reprogramming during cellular differentiation. Twit Text FOAVip 5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25263596 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25263596 #FOAvip English Wikipedia <ref>{{Cite pmid|25263596 }}</ref> 5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation #MMPMID25263596 Hon GC ; Song CX ; Du T ; Jin F ; Selvaraj S ; Lee AY ; Yen CA ; Ye Z ; Mao SQ ; Wang BA ; Kuan S ; Edsall LE ; Zhao BS ; Xu GL ; He C ; Ren B Mol Cell 2014[Oct]; 56 (2 ): 286-297 PMID25263596 show ga In mammals, cytosine methylation (5mC) is widely distributed throughout the genome but is notably depleted from active promoters and enhancers. While the role of DNA methylation in promoter silencing has been well documented, the function of this epigenetic mark at enhancers remains unclear. Recent experiments have demonstrated that enhancers are enriched for 5-hydroxymethylcytosine (5hmC), an oxidization product of the Tet family of 5mC dioxygenases and an intermediate of DNA demethylation. These results support the involvement of Tet proteins in the regulation of dynamic DNA methylation at enhancers. By mapping DNA methylation and hydroxymethylation at base resolution, we find that deletion of Tet2 causes extensive loss of 5hmC at enhancers, accompanied by enhancer hypermethylation, reduction of enhancer activity, and delayed gene induction in the early steps of differentiation. Our results reveal that DNA demethylation modulates enhancer activity, and its disruption influences the timing of transcriptome reprogramming during cellular differentiation. |5-Methylcytosine/metabolism [MESH] |Animals [MESH] |Base Sequence [MESH] |Cell Differentiation/*genetics [MESH] |Cell Line [MESH] |Cytosine/analogs & derivatives/metabolism [MESH] |DNA Methylation/*genetics [MESH] |DNA-Binding Proteins/genetics/*metabolism [MESH] |Dioxygenases [MESH] |Enhancer Elements, Genetic/*genetics [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Oxidation-Reduction [MESH] |Promoter Regions, Genetic/genetics [MESH] |Proto-Oncogene Proteins/genetics/*metabolism [MESH] |Sequence Analysis, DNA [MESH] |Transcriptome/genetics [MESH]5mC oxidation by Tet2 modulates enhancer activity and timing of transc(epmc).pdf DeepDyve Pubget Overpricing