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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Genes+Dev 2015 ; 29 (3): 308-21 Nephropedia Template TP
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PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1 #MMPMID25644605
Iida S; Chen W; Nakadai T; Ohkuma Y; Roeder RG
Genes Dev 2015[Feb]; 29 (3): 308-21 PMID25644605show ga
PRDM16 induces expression of brown fat-specific genes in brown and beige adipocytes. Here, Iida et al. show that PRDM16, through its zinc finger domains, directly interacts with the MED1 subunit of the Mediator complex and is recruited to the enhancer of the brown fat-specific Ucp1 gene through this interaction. This enhances thyroid hormone receptor-driven transcription in a biochemically defined system in a Mediator-dependent manner, thus providing a direct link to the general transcription machinery.