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10.1101/gad.252809.114

http://scihub22266oqcxt.onion/10.1101/gad.252809.114
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C4318147!4318147!25644605
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suck abstract from ncbi


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pmid25644605      Genes+Dev 2015 ; 29 (3): 308-21
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  • PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1 #MMPMID25644605
  • Iida S; Chen W; Nakadai T; Ohkuma Y; Roeder RG
  • Genes Dev 2015[Feb]; 29 (3): 308-21 PMID25644605show ga
  • PRDM16 induces expression of brown fat-specific genes in brown and beige adipocytes. Here, Iida et al. show that PRDM16, through its zinc finger domains, directly interacts with the MED1 subunit of the Mediator complex and is recruited to the enhancer of the brown fat-specific Ucp1 gene through this interaction. This enhances thyroid hormone receptor-driven transcription in a biochemically defined system in a Mediator-dependent manner, thus providing a direct link to the general transcription machinery.
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