Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1101/gad.252734.114 http://scihub22266oqcxt.onion/10.1101/gad.252734.114 C4318146!4318146 !25644604     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25644604 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Dev 2015 ; 29 (3 ): 298-307 Nephropedia Template TP {{tp|p=25644604 |t=2015. PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program |pdf=|usr=}}{{25644604 }} gab.com Text PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25644604 #FOAvip PR (PRD1-BF1-RIZ1 homologous) domain-containing 16 (PRDM16) drives a brown fat differentiation program, but the mechanisms by which PRDM16 activates brown fat-selective genes have been unclear. Through chromatin immunoprecipitation (ChIP) followed by deep sequencing (ChIP-seq) analyses in brown adipose tissue (BAT), we reveal that PRDM16 binding is highly enriched at a broad set of brown fat-selective genes. Importantly, we found that PRDM16 physically binds to MED1, a component of the Mediator complex, and recruits it to superenhancers at brown fat-selective genes. PRDM16 deficiency in BAT reduces MED1 binding at PRDM16 target sites and causes a fundamental change in chromatin architecture at key brown fat-selective genes. Together, these data indicate that PRDM16 controls chromatin architecture and superenhancer activity in BAT. Twit Text FOAVip PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25644604 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25644604 #FOAvip English Wikipedia <ref>{{Cite pmid|25644604 }}</ref> PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program #MMPMID25644604 Harms MJ ; Lim HW ; Ho Y ; Shapira SN ; Ishibashi J ; Rajakumari S ; Steger DJ ; Lazar MA ; Won KJ ; Seale P Genes Dev 2015[Feb]; 29 (3 ): 298-307 PMID25644604 show ga PR (PRD1-BF1-RIZ1 homologous) domain-containing 16 (PRDM16) drives a brown fat differentiation program, but the mechanisms by which PRDM16 activates brown fat-selective genes have been unclear. Through chromatin immunoprecipitation (ChIP) followed by deep sequencing (ChIP-seq) analyses in brown adipose tissue (BAT), we reveal that PRDM16 binding is highly enriched at a broad set of brown fat-selective genes. Importantly, we found that PRDM16 physically binds to MED1, a component of the Mediator complex, and recruits it to superenhancers at brown fat-selective genes. PRDM16 deficiency in BAT reduces MED1 binding at PRDM16 target sites and causes a fundamental change in chromatin architecture at key brown fat-selective genes. Together, these data indicate that PRDM16 controls chromatin architecture and superenhancer activity in BAT. |Adipose Tissue, Brown/*metabolism [MESH] |Animals [MESH] |Chromatin/chemistry/genetics/*metabolism [MESH] |DNA-Binding Proteins/*metabolism [MESH] |Enhancer Elements, Genetic [MESH] |Mediator Complex Subunit 1/*metabolism [MESH] |Mice [MESH] |Transcription Factors/*metabolism [MESH]PRDM16 binds MED1 and controls chromatin architecture to determine a b(epmc).pdf DeepDyve Pubget Overpricing