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TGF-?/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis #MMPMID25644601
Yu JR; Tai Y; Jin Y; Hammell MC; Wilkinson JE; Roe JS; Vakoc CR; Van Aelst L
Genes Dev 2015[Feb]; 29 (3): 250-61 PMID25644601show ga
Yu et al. report that in lung adenocarcinoma (ADC) cells, TGF-? potently induces expression of DOCK4, but not other DOCK family members, via the Smad pathway. TGF-?-induced DOCK4 stimulates lung ADC cell protrusion, motility, and invasion without affecting epithelial-to-mesenchymal transition. These processes are driven by DOCK4-mediated Rac1 activation, unveiling a novel link between TGF-? and Rac1.