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10.1111/cas.12541 http://scihub22266oqcxt.onion/10.1111/cas.12541 C4317966!4317966!25250919     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Sci 2014 ; 105 (12): 1526-32 Nephropedia Template TP {{tp|p=25250919|t=2014. Silencing of STRN4 suppresses the malignant characteristics of cancer cells |pdf=|usr=}}{{25250919}} gab.com Text Silencing of STRN4 suppresses the malignant characteristics of cancer cells JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=25250919 #FOAvip The striatin family of proteins, comprising STRN, STRN3 and STRN4, are multidomain-containing proteins that associate with additional proteins to form a large protein complex. We previously reported that STRN4 directly associated with protein kinases, such as MINK1, TNIK and MAP4K4, which are associated with tumor suppression or tumor progression. However, it remains unclear whether STRN4 is associated with tumor progression. In this report, we examined the role that STRN4 plays in cancer malignancy. We show that depletion of STRN4 suppresses proliferation, migration, invasion and the anchorage-independent growth of cancer cells. In addition, STRN4 knockdown increases the sensitivity of pancreatic cancer cells to gemcitabine. Finally, we show that STRN4 knockdown suppresses the proliferation and metastasis of cancer cells in mice. Our results demonstrate a possible role of STRN4 in tumor progression. Twit Text FOAVip Silencing of STRN4 suppresses the malignant characteristics of cancer cells ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=25250919 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25250919 #FOAvip English Wikipedia <ref>{{Cite pmid|25250919}}</ref> Silencing of STRN4 suppresses the malignant characteristics of cancer cells #MMPMID25250919 Wong M; Hyodo T; Asano E; Funasaka K; Miyahara R; Hirooka Y; Goto H; Hamaguchi M; Senga T Cancer Sci 2014[Dec]; 105 (12): 1526-32 PMID25250919show ga The striatin family of proteins, comprising STRN, STRN3 and STRN4, are multidomain-containing proteins that associate with additional proteins to form a large protein complex. We previously reported that STRN4 directly associated with protein kinases, such as MINK1, TNIK and MAP4K4, which are associated with tumor suppression or tumor progression. However, it remains unclear whether STRN4 is associated with tumor progression. In this report, we examined the role that STRN4 plays in cancer malignancy. We show that depletion of STRN4 suppresses proliferation, migration, invasion and the anchorage-independent growth of cancer cells. In addition, STRN4 knockdown increases the sensitivity of pancreatic cancer cells to gemcitabine. Finally, we show that STRN4 knockdown suppresses the proliferation and metastasis of cancer cells in mice. Our results demonstrate a possible role of STRN4 in tumor progression. äSilencing of STRN4 suppresses the malignant characteristics of cancer (epmc).pdf DeepDyve Pubget Overpricing