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10.1111/cas.12441 http://scihub22266oqcxt.onion/10.1111/cas.12441 C4317931!4317931 !24815849     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24815849 &cmd=llinks): Failed to open stream: HTTP request failed! 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Tumor-suppressive microRNA-218 inhibits cancer cell migration and invasion via targeting of LASP1 in prostate cancer |pdf=|usr=}}{{24815849 }} gab.com Text Tumor-suppressive microRNA-218 inhibits cancer cell migration and invasion via targeting of LASP1 in prostate cancer JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=24815849 #FOAvip Our recent studies of the microRNA (miRNA) expression signature in prostate cancer (PCa) indicated that miRNA-218 (miR-218) was significantly downregulated in clinical specimens, suggesting that miR-218 might act as a tumor-suppressive miRNA in PCa. The aim of the present study was to investigate the functional significance of miR-218 in PCa and to identify novel miR-218-regulated cancer pathways and target genes involved in PCa oncogenesis and metastasis. Restoration of miR-218 in PCa cell lines (PC3 and DU145) revealed that this miRNA significantly inhibited cancer cell migration and invasion. Gene expression data and in silico analysis demonstrated that LIM and SH3 protein 1 (LASP1) is a potential target of miR-218 regulation. LASP1 is a cytoskeletal scaffold protein that plays critical roles in cytoskeletal organization and cell migration. Luciferase reporter assays showed that miR-218 directly regulated expression of LASP1. Moreover, downregulating the LASP1 gene significantly inhibited cell migration and invasion in cancer cells, and the expression of LASP1 was upregulated in cancer tissues. We conclude that loss of tumor-suppressive miR-218 enhanced cancer cell migration and invasion in PCa through direct regulation of LASP1. Our data on pathways regulated by tumor-suppressive miR-218 provide new insight into the potential mechanisms of PCa oncogenesis and metastasis. Twit Text FOAVip Tumor-suppressive microRNA-218 inhibits cancer cell migration and invasion via targeting of LASP1 in prostate cancer ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=24815849 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24815849 #FOAvip English Wikipedia <ref>{{Cite pmid|24815849 }}</ref> Tumor-suppressive microRNA-218 inhibits cancer cell migration and invasion via targeting of LASP1 in prostate cancer #MMPMID24815849 Nishikawa R ; Goto Y ; Sakamoto S ; Chiyomaru T ; Enokida H ; Kojima S ; Kinoshita T ; Yamamoto N ; Nakagawa M ; Naya Y ; Ichikawa T ; Seki N Cancer Sci 2014[Jul]; 105 (7 ): 802-11 PMID24815849 show ga Our recent studies of the microRNA (miRNA) expression signature in prostate cancer (PCa) indicated that miRNA-218 (miR-218) was significantly downregulated in clinical specimens, suggesting that miR-218 might act as a tumor-suppressive miRNA in PCa. The aim of the present study was to investigate the functional significance of miR-218 in PCa and to identify novel miR-218-regulated cancer pathways and target genes involved in PCa oncogenesis and metastasis. Restoration of miR-218 in PCa cell lines (PC3 and DU145) revealed that this miRNA significantly inhibited cancer cell migration and invasion. Gene expression data and in silico analysis demonstrated that LIM and SH3 protein 1 (LASP1) is a potential target of miR-218 regulation. LASP1 is a cytoskeletal scaffold protein that plays critical roles in cytoskeletal organization and cell migration. Luciferase reporter assays showed that miR-218 directly regulated expression of LASP1. Moreover, downregulating the LASP1 gene significantly inhibited cell migration and invasion in cancer cells, and the expression of LASP1 was upregulated in cancer tissues. We conclude that loss of tumor-suppressive miR-218 enhanced cancer cell migration and invasion in PCa through direct regulation of LASP1. Our data on pathways regulated by tumor-suppressive miR-218 provide new insight into the potential mechanisms of PCa oncogenesis and metastasis. |*Gene Expression Regulation, Neoplastic [MESH] |Adaptor Proteins, Signal Transducing/genetics/*metabolism [MESH] |Aged [MESH] |Cell Movement/genetics [MESH] |Cell Proliferation [MESH] |Cytoskeletal Proteins/genetics/*metabolism [MESH] |Humans [MESH] |LIM Domain Proteins/genetics/*metabolism [MESH] |Male [MESH] |MicroRNAs/*genetics [MESH] |Middle Aged [MESH] |Molecular Sequence Data [MESH] |Prostatic Neoplasms/*genetics/*pathology [MESH]Tumor-suppressive microRNA-218 inhibits cancer cell migration and inva(epmc).pdf DeepDyve Pubget Overpricing