Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24815301
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24815301
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cancer+Sci
2014 ; 105
(7
): 847-56
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Novel regulatory program for norepinephrine-induced epithelial-mesenchymal
transition in gastric adenocarcinoma cell lines
#MMPMID24815301
Shan T
; Cui X
; Li W
; Lin W
; Li Y
; Chen X
; Wu T
Cancer Sci
2014[Jul]; 105
(7
): 847-56
PMID24815301
show ga
Norepinephrine and epinephrine, catecholamine hormones that are major mediators
for chronic stress-induced cancers, are implicated in the progression of a number
of cancer cells, including gastric adenocarcinoma. However, the underlying
mechanisms of these hormones have not been well elucidated.
Epithelial-mesenchymal transition (EMT) is a crucial event responsible for cancer
cell invasion and metastasis. The hypothesis regarding whether the promotive
effects of norepinephrine (NE) on cancer are in part due to its ability to induce
an EMT program has not been proven. In this study, we show that NE does not only
obviously induce EMT alterations in the morphological characteristics of gastric
adenocarcinoma cells, but also increases the markers of EMT, including vimentin
expression, and decreases E-cadherin expression, further resulting in cell
motility and invasiveness. We also reveal that these actions are mainly mediated
through the activation of ?2 -AR-HIF-1?-Snail signaling pathways. In summary,
this study implies that NE induces EMT in gastric adenocarcinoma through the
regulation of ?2 -AR-HIF-1?-Snail activity. The data provide a new perspective on
chronic stress in a negative social and psychological state, which may be a risk
factor for cancer development and progression.
free
free
free
