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10.1038/nm.3733 http://scihub22266oqcxt.onion/10.1038/nm.3733 C4313872!4313872!25326804     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2014 ; 20 (12): 1472-8 Nephropedia Template TP {{tp|p=25326804|t=2014. Age-related cancer mutations associated with clonal hematopoietic expansion |pdf=|usr=}}{{25326804}} gab.com Text Age-related cancer mutations associated with clonal hematopoietic expansion JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=25326804 #FOAvip Several genetic alterations characteristic of leukemia and lymphoma have been detected in the blood of individuals without apparent hematological malignancies. We analyzed blood-derived sequence data from 2,728 individuals within The Cancer Genome Atlas, and discovered 77 blood-specific mutations in cancer-associated genes, the majority being associated with advanced age. Remarkably, 83% of these mutations were from 19 leukemia/lymphoma-associated genes, and nine were recurrently mutated (DNMT3A, TET2, JAK2, ASXL1, TP53, GNAS, PPM1D, BCORL1 and SF3B1). We identified 14 additional mutations in a very small fraction of blood cells, possibly representing the earliest stages of clonal expansion in hematopoietic stem cells. Comparison of these findings to mutations in hematological malignancies identified several recurrently mutated genes that may be disease initiators. Our analyses show that the blood cells of more than 2% of individuals (5?6% of people older than 70 years) contain mutations that may represent premalignant, initiating events that cause clonal hematopoietic expansion. Twit Text FOAVip Age-related cancer mutations associated with clonal hematopoietic expansion ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=25326804 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25326804 #FOAvip English Wikipedia <ref>{{Cite pmid|25326804}}</ref> Age-related cancer mutations associated with clonal hematopoietic expansion #MMPMID25326804 Xie M; Lu C; Wang J; McLellan MD; Johnson KJ; Wendl MC; McMichael JF; Schmidt HK; Yellapantula V; Miller CA; Ozenberger BA; Welch JS; Link DC; Walter MJ; Mardis ER; Dipersio JF; Chen F; Wilson RK; Ley TJ; Ding L Nat Med 2014[Dec]; 20 (12): 1472-8 PMID25326804show ga Several genetic alterations characteristic of leukemia and lymphoma have been detected in the blood of individuals without apparent hematological malignancies. We analyzed blood-derived sequence data from 2,728 individuals within The Cancer Genome Atlas, and discovered 77 blood-specific mutations in cancer-associated genes, the majority being associated with advanced age. Remarkably, 83% of these mutations were from 19 leukemia/lymphoma-associated genes, and nine were recurrently mutated (DNMT3A, TET2, JAK2, ASXL1, TP53, GNAS, PPM1D, BCORL1 and SF3B1). We identified 14 additional mutations in a very small fraction of blood cells, possibly representing the earliest stages of clonal expansion in hematopoietic stem cells. Comparison of these findings to mutations in hematological malignancies identified several recurrently mutated genes that may be disease initiators. Our analyses show that the blood cells of more than 2% of individuals (5?6% of people older than 70 years) contain mutations that may represent premalignant, initiating events that cause clonal hematopoietic expansion. äAge-related cancer mutations associated with clonal hematopoietic expa(epmc).pdf DeepDyve Pubget Overpricing