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10.1073/pnas.1415020112

http://scihub22266oqcxt.onion/10.1073/pnas.1415020112
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C4313816!4313816!25583514
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suck abstract from ncbi


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pmid25583514      Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (4): 1065-70
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  • Impaired Hippo signaling promotes Rho1?JNK-dependent growth #MMPMID25583514
  • Ma X; Chen Y; Xu W; Wu N; Li M; Cao Y; Wu S; Li Q; Xue L
  • Proc Natl Acad Sci U S A 2015[Jan]; 112 (4): 1065-70 PMID25583514show ga
  • Both Hippo and c-Jun N-terminal kinase (JNK) signaling have well-established roles in promoting tissue growth, while it remains elusive whether and how the two pathways interact or coordinate in growth control. We report in the present study that the Hpo?Yki pathway modulates Rho1?JNK signaling-mediated growth in Drosophila wing development. We show that the impaired Hpo pathway activates JNK through transcriptional up-regulation of Rho1. These findings expands our understanding about the cross-talk between two important signaling pathways, namely Hippo?Yki and Rho1?JNK, in regulating growth.
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