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10.1016/j.bbadis.2014.11.020 http://scihub22266oqcxt.onion/10.1016/j.bbadis.2014.11.020 C4312720!4312720!25481835     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 2015 ; 1852 (3): 406-20 Nephropedia Template TP {{tp|p=25481835|t=2015. Usher syndrome: hearing loss, retinal degeneration and associated abnormalities |pdf=|usr=}}{{25481835}} gab.com Text Usher syndrome: hearing loss, retinal degeneration and associated abnormalities JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=25481835 #FOAvip Usher syndrome (USH), clinically and genetically heterogeneous, is the leading genetic cause of combined hearing and vision loss. USH is classified into three types, based on the hearing and vestibular symptoms observed in patients. Sixteen loci have been reported to be involved in the occurrence of USH and atypical USH. Among them, twelve have been identified as causative genes and one as a modifier gene. Studies on the proteins encoded by these USH genes suggest that USH proteins interact among one another and function in multiprotein complexes in vivo. Although their exact functions remain enigmatic in the retina, USH proteins are required for the development, maintenance and function of hair bundles, which are the primary mechanosensitive structure of inner ear hair cells. Despite the unavailability of a cure, progress has been made to develop effective treatments for this disease. In this review, we focus on the most recent discoveries in the field with an emphasis on USH genes, protein complexes and functions in various tissues as well as progress toward therapeutic development for USH. Twit Text FOAVip Usher syndrome: hearing loss, retinal degeneration and associated abnormalities ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=25481835 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25481835 #FOAvip English Wikipedia <ref>{{Cite pmid|25481835}}</ref> Usher syndrome: hearing loss, retinal degeneration and associated abnormalities #MMPMID25481835 Mathur P; Yang J Biochim Biophys Acta 2015[Mar]; 1852 (3): 406-20 PMID25481835show ga Usher syndrome (USH), clinically and genetically heterogeneous, is the leading genetic cause of combined hearing and vision loss. USH is classified into three types, based on the hearing and vestibular symptoms observed in patients. Sixteen loci have been reported to be involved in the occurrence of USH and atypical USH. Among them, twelve have been identified as causative genes and one as a modifier gene. Studies on the proteins encoded by these USH genes suggest that USH proteins interact among one another and function in multiprotein complexes in vivo. Although their exact functions remain enigmatic in the retina, USH proteins are required for the development, maintenance and function of hair bundles, which are the primary mechanosensitive structure of inner ear hair cells. Despite the unavailability of a cure, progress has been made to develop effective treatments for this disease. In this review, we focus on the most recent discoveries in the field with an emphasis on USH genes, protein complexes and functions in various tissues as well as progress toward therapeutic development for USH. äUsher syndrome: hearing loss, retinal degeneration and associated abno(epmc).pdf DeepDyve Pubget Overpricing