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10.1038/ncomms7072 http://scihub22266oqcxt.onion/10.1038/ncomms7072 C4311884!4311884!25614966     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): 6072 Nephropedia Template TP {{tp|p=25614966|t=2015. An IL-27/NFIL3 signaling axis drives Tim-3 and IL-10 expression and T cell dysfunction |pdf=|usr=}}{{25614966}} gab.com Text An IL-27/NFIL3 signaling axis drives Tim-3 and IL-10 expression and T cell dysfunction JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25614966 #FOAvip The inhibitory receptor Tim-3 has emerged as a critical regulator of the T cell dysfunction that develops in chronic viral infections and cancers. However, little is known regarding the signaling pathways that drive Tim-3 expression. Here, we demonstrate that IL-27 induces NFIL3, which promotes permissive chromatin remodeling of the Tim-3 locus and induces Tim-3 expression together with the immunosuppressive cytokine IL-10. We further show that the IL-27/NFIL3 signaling axis is crucial for the induction of Tim-3 in vivo. IL-27-conditioned Th1 cells exhibit reduced effector function and are poor mediators of intestinal inflammation. This inhibitory effect is NFIL3 dependent. In contrast, tumor-infiltrating lymphocytes (TILs) from IL-27R?/? mice exhibit reduced NFIL3, less Tim-3 expression and failure to develop dysfunctional phenotype, resulting in better tumor growth control. Thus, our data identify an IL-27/NFIL3 signaling axis as a key regulator of effector T cell responses via induction of Tim-3, IL-10, and T cell dysfunction. Twit Text FOAVip An IL-27/NFIL3 signaling axis drives Tim-3 and IL-10 expression and T cell dysfunction ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25614966 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25614966 #FOAvip English Wikipedia <ref>{{Cite pmid|25614966}}</ref> An IL-27/NFIL3 signaling axis drives Tim-3 and IL-10 expression and T cell dysfunction #MMPMID25614966 Zhu C; Sakuishi K; Xiao S; Sun Z; Zaghouani S; Gu G; Wang C; Tan DJ; Wu C; Rangachari M; Pertel T; Jin HT; Ahmed R; Anderson AC; Kuchroo VK Nat Commun 2015[]; 6 (ä): 6072 PMID25614966show ga The inhibitory receptor Tim-3 has emerged as a critical regulator of the T cell dysfunction that develops in chronic viral infections and cancers. However, little is known regarding the signaling pathways that drive Tim-3 expression. Here, we demonstrate that IL-27 induces NFIL3, which promotes permissive chromatin remodeling of the Tim-3 locus and induces Tim-3 expression together with the immunosuppressive cytokine IL-10. We further show that the IL-27/NFIL3 signaling axis is crucial for the induction of Tim-3 in vivo. IL-27-conditioned Th1 cells exhibit reduced effector function and are poor mediators of intestinal inflammation. This inhibitory effect is NFIL3 dependent. In contrast, tumor-infiltrating lymphocytes (TILs) from IL-27R?/? mice exhibit reduced NFIL3, less Tim-3 expression and failure to develop dysfunctional phenotype, resulting in better tumor growth control. Thus, our data identify an IL-27/NFIL3 signaling axis as a key regulator of effector T cell responses via induction of Tim-3, IL-10, and T cell dysfunction. äAn IL-27/NFIL3 signaling axis drives Tim-3 and IL-10 expression and T (epmc).pdf DeepDyve Pubget Overpricing