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10.1073/pnas.1415673112 http://scihub22266oqcxt.onion/10.1073/pnas.1415673112 C4311818!4311818!25561556     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (3): E329-37 Nephropedia Template TP {{tp|p=25561556|t=2015. Intracellular Cl? as a signaling ion that potently regulates Na+/HCO3? transporters |pdf=|usr=}}{{25561556}} gab.com Text Intracellular Cl as a signaling ion that potently regulates Na+/HCO3 transporters JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25561556 #FOAvip Cl? is the major cellular anion that controls the intracellular activity of many ions, the membrane potential, and transepithelial fluid and electrolyte secretion. How cells sense intracellular Cl? (Cl?in) to coordinate all Cl?-dependent activities is not known. We report a molecular mechanism for Cl?in sensing that involves interaction of Cl? with GXXXP-containing sites and show how these sites are used to regulate the activity of several Na+-HCO3? cotransporters. Although these transporters do not transport Cl?, they sense Cl?in in a manner specific for each transporter that is suitable for the transporter physiological activity. Our data has fundamental implications for the role of Cl? in cellular ion homeostasis and fluid and electrolyte secretion. Twit Text FOAVip Intracellular Cl as a signaling ion that potently regulates Na+/HCO3 transporters ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25561556 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25561556 #FOAvip English Wikipedia <ref>{{Cite pmid|25561556}}</ref> Intracellular Cl? as a signaling ion that potently regulates Na+/HCO3? transporters #MMPMID25561556 Shcheynikov N; Son A; Hong JH; Yamazaki O; Ohana E; Kurtz I; Shin DM; Muallem S Proc Natl Acad Sci U S A 2015[Jan]; 112 (3): E329-37 PMID25561556show ga Cl? is the major cellular anion that controls the intracellular activity of many ions, the membrane potential, and transepithelial fluid and electrolyte secretion. How cells sense intracellular Cl? (Cl?in) to coordinate all Cl?-dependent activities is not known. We report a molecular mechanism for Cl?in sensing that involves interaction of Cl? with GXXXP-containing sites and show how these sites are used to regulate the activity of several Na+-HCO3? cotransporters. Although these transporters do not transport Cl?, they sense Cl?in in a manner specific for each transporter that is suitable for the transporter physiological activity. Our data has fundamental implications for the role of Cl? in cellular ion homeostasis and fluid and electrolyte secretion. äIntracellular Cl? as a signaling ion that potently regulates Na+/HCO3?(epmc).pdf DeepDyve Pubget Overpricing