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10.1091/mbc.E14-06-1088 http://scihub22266oqcxt.onion/10.1091/mbc.E14-06-1088 C4310746!4310746 !25428989     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25428989 &cmd=llinks): Failed to open stream: HTTP request failed! 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PAS kinase is activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1 |pdf=|usr=}}{{25428989 }} gab.com Text PAS kinase is activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1 JO: Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25428989 #FOAvip We describe the interplay between three sensory protein kinases in yeast: AMP-regulated kinase (AMPK, or SNF1 in yeast), PAS kinase 1 (Psk1 in yeast), and the target of rapamycin complex 1 (TORC1). This signaling cascade occurs through the SNF1-dependent phosphorylation and activation of Psk1, which phosphorylates and activates poly(A)- binding protein binding protein 1 (Pbp1), which then inhibits TORC1 through sequestration at stress granules. The SNF1-dependent phosphorylation of Psk1 appears to be direct, in that Snf1 is necessary and sufficient for Psk1 activation by alternate carbon sources, is required for altered Psk1 protein mobility, is able to phosphorylate Psk1 in vitro, and binds Psk1 via its substrate-targeting subunit Gal83. Evidence for the direct phosphorylation and activation of Pbp1 by Psk1 is also provided by in vitro and in vivo kinase assays, including the reduction of Pbp1 localization at distinct cytoplasmic foci and subsequent rescue of TORC1 inhibition in PAS kinase-deficient yeast. In support of this signaling cascade, Snf1-deficient cells display increased TORC1 activity, whereas cells containing hyperactive Snf1 display a PAS kinase-dependent decrease in TORC1 activity. This interplay between yeast SNF1, Psk1, and TORC1 allows for proper glucose allocation during nutrient depletion, reducing cell growth and proliferation when energy is low. Twit Text FOAVip PAS kinase is activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1 ????Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25428989 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25428989 #FOAvip English Wikipedia <ref>{{Cite pmid|25428989 }}</ref> PAS kinase is activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1 #MMPMID25428989 DeMille D ; Badal BD ; Evans JB ; Mathis AD ; Anderson JF ; Grose JH Mol Biol Cell 2015[Feb]; 26 (3 ): 569-82 PMID25428989 show ga We describe the interplay between three sensory protein kinases in yeast: AMP-regulated kinase (AMPK, or SNF1 in yeast), PAS kinase 1 (Psk1 in yeast), and the target of rapamycin complex 1 (TORC1). This signaling cascade occurs through the SNF1-dependent phosphorylation and activation of Psk1, which phosphorylates and activates poly(A)- binding protein binding protein 1 (Pbp1), which then inhibits TORC1 through sequestration at stress granules. The SNF1-dependent phosphorylation of Psk1 appears to be direct, in that Snf1 is necessary and sufficient for Psk1 activation by alternate carbon sources, is required for altered Psk1 protein mobility, is able to phosphorylate Psk1 in vitro, and binds Psk1 via its substrate-targeting subunit Gal83. Evidence for the direct phosphorylation and activation of Pbp1 by Psk1 is also provided by in vitro and in vivo kinase assays, including the reduction of Pbp1 localization at distinct cytoplasmic foci and subsequent rescue of TORC1 inhibition in PAS kinase-deficient yeast. In support of this signaling cascade, Snf1-deficient cells display increased TORC1 activity, whereas cells containing hyperactive Snf1 display a PAS kinase-dependent decrease in TORC1 activity. This interplay between yeast SNF1, Psk1, and TORC1 allows for proper glucose allocation during nutrient depletion, reducing cell growth and proliferation when energy is low. |Carrier Proteins/*metabolism [MESH] |Cell Proliferation [MESH] |Down-Regulation [MESH] |Enzyme Activation [MESH] |Glucose/*metabolism [MESH] |Mechanistic Target of Rapamycin Complex 1 [MESH] |Multiprotein Complexes/antagonists & inhibitors/*metabolism [MESH] |Phosphorylation [MESH] |Protein Kinases/*metabolism [MESH] |Protein Serine-Threonine Kinases/*metabolism [MESH] |Saccharomyces cerevisiae Proteins/*metabolism [MESH] |Saccharomyces cerevisiae/enzymology/growth & development/metabolism [MESH] |Signal Transduction [MESH]PAS kinase is activated by direct SNF1-dependent phosphorylation and m(epmc).pdf DeepDyve Pubget Overpricing