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10.1016/j.ijid.2014.10.015 http://scihub22266oqcxt.onion/10.1016/j.ijid.2014.10.015 C4310697!4310697!25447732     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Infect+Dis 2014 ; ä (ä): 259-67 Nephropedia Template TP {{tp|p=25447732|t=2014. Role of innate immunity in the pathogenesis of otitis media |pdf=|usr=}}{{25447732}} gab.com Text Role of innate immunity in the pathogenesis of otitis media JO: Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=25447732 #FOAvip Otitis media (OM) is a public health problem in both developed and developing countries. It is the leading cause of hearing loss and represents a significant healthcare burden. In some cases, acute OM progresses to chronic suppurative OM (CSOM), characterized by effusion and discharge, despite antimicrobial therapy. The emergence of antibiotic resistance and potential ototoxicity of antibiotics has created an urgent need to design non-conventional therapeutic strategies against OM based on modern insights into its pathophysiology. In this article, we review the role of innate immunity as it pertains to OM and discuss recent advances in understanding the role of innate immune cells in protecting the middle ear. We also discuss the mechanisms utilized by pathogens to subvert innate immunity and thereby overcome defensive responses. A better knowledge about bacterial virulence and host resistance promises to reveal novel targets to design effective treatment strategies against OM. The identification and characterization of small natural compounds that can boost innate immunity may provide new avenues for the treatment of OM. There is also a need to design novel methods for targeted delivery of these compounds into the middle ear, allowing higher therapeutic doses and minimizing systemic side effects. Twit Text FOAVip Role of innate immunity in the pathogenesis of otitis media ????Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=25447732 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25447732 #FOAvip English Wikipedia <ref>{{Cite pmid|25447732}}</ref> Role of innate immunity in the pathogenesis of otitis media #MMPMID25447732 Mittal R; Kodiyan J; Gerring R; Mathee K; Li JD; Grati M; Liu XZ Int J Infect Dis 2014[Dec]; ä (ä): 259-67 PMID25447732show ga Otitis media (OM) is a public health problem in both developed and developing countries. It is the leading cause of hearing loss and represents a significant healthcare burden. In some cases, acute OM progresses to chronic suppurative OM (CSOM), characterized by effusion and discharge, despite antimicrobial therapy. The emergence of antibiotic resistance and potential ototoxicity of antibiotics has created an urgent need to design non-conventional therapeutic strategies against OM based on modern insights into its pathophysiology. In this article, we review the role of innate immunity as it pertains to OM and discuss recent advances in understanding the role of innate immune cells in protecting the middle ear. We also discuss the mechanisms utilized by pathogens to subvert innate immunity and thereby overcome defensive responses. A better knowledge about bacterial virulence and host resistance promises to reveal novel targets to design effective treatment strategies against OM. The identification and characterization of small natural compounds that can boost innate immunity may provide new avenues for the treatment of OM. There is also a need to design novel methods for targeted delivery of these compounds into the middle ear, allowing higher therapeutic doses and minimizing systemic side effects. äRole of innate immunity in the pathogenesis of otitis media (epmc).pdf DeepDyve Pubget Overpricing