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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 ACS+Nano 2015 ; 9 (1): 251-9 Nephropedia Template TP
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Triggering of RNA Interference with RNA?RNA, RNA?DNA, and DNA?RNA Nanoparticles #MMPMID25521794
Afonin KA; Viard M; Kagiampakis I; Case CL; Dobrovolskaia MA; Hofmann J; Vrzak A; Kireeva M; Kasprzak WK; KewalRamani VN; Shapiro BA
ACS Nano 2015[Jan]; 9 (1): 251-9 PMID25521794show ga
Control over cellular delivery of different functionalities and their synchronized activation is a challenging task. We report several RNA and RNA/DNA-based nanoparticles designed to conditionally activate the RNA interference in various human cells. These nanoparticles allow precise control over their formulation, stability in blood serum, and activation of multiple functionalities. Importantly, interferon and pro-inflammatory cytokine activation assays indicate the significantly lower responses for DNA nanoparticles compared to the RNA counterparts, suggesting greater potential of these molecules for therapeutic use.