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10.1016/j.immuni.2014.12.005 http://scihub22266oqcxt.onion/10.1016/j.immuni.2014.12.005 C4309019!4309019 !25526313     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25526313 &cmd=llinks): Failed to open stream: HTTP request failed! 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The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells |pdf=|usr=}}{{25526313 }} gab.com Text The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25526313 #FOAvip The receptor CTLA-4 has been implicated in controlling B cell responses, but the mechanisms by which CTLA-4 regulates antibody production are not known. Here we showed deletion of CTLA-4 in adult mice increased Tfh and Tfr cell numbers and augmented B cell responses. In the effector phase, loss of CTLA-4 on Tfh cells resulted in heightened B cell responses, whereas loss of CTLA-4 on Tfr cells resulted in defective suppression of antigen-specific antibody responses. We also found that non-Tfr Treg cells could suppress B cell responses through CTLA-4 and that Treg and/or Tfr cells might downregulate B7-2 on B cells outside germinal centers as a means of suppression. Within the germinal center, however, Tfr cells potently suppress B cells through CTLA-4, but with a mechanism independent of altering B7-1 or B7-2. Thus, we identify multifaceted regulatory roles for CTLA-4 in Tfh, Tfr, and Treg cells, which together control humoral immunity. Twit Text FOAVip The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25526313 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25526313 #FOAvip English Wikipedia <ref>{{Cite pmid|25526313 }}</ref> The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells #MMPMID25526313 Sage PT ; Paterson AM ; Lovitch SB ; Sharpe AH Immunity 2014[Dec]; 41 (6 ): 1026-39 PMID25526313 show ga The receptor CTLA-4 has been implicated in controlling B cell responses, but the mechanisms by which CTLA-4 regulates antibody production are not known. Here we showed deletion of CTLA-4 in adult mice increased Tfh and Tfr cell numbers and augmented B cell responses. In the effector phase, loss of CTLA-4 on Tfh cells resulted in heightened B cell responses, whereas loss of CTLA-4 on Tfr cells resulted in defective suppression of antigen-specific antibody responses. We also found that non-Tfr Treg cells could suppress B cell responses through CTLA-4 and that Treg and/or Tfr cells might downregulate B7-2 on B cells outside germinal centers as a means of suppression. Within the germinal center, however, Tfr cells potently suppress B cells through CTLA-4, but with a mechanism independent of altering B7-1 or B7-2. Thus, we identify multifaceted regulatory roles for CTLA-4 in Tfh, Tfr, and Treg cells, which together control humoral immunity. |Animals [MESH] |Antibody Formation [MESH] |B-Lymphocytes/*immunology [MESH] |B7-1 Antigen/genetics/metabolism [MESH] |B7-2 Antigen/genetics/metabolism [MESH] |CTLA-4 Antigen/genetics/*metabolism [MESH] |Cell Differentiation [MESH] |Cells, Cultured [MESH] |Down-Regulation [MESH] |Germinal Center/*immunology [MESH] |Immune Tolerance [MESH] |Mice [MESH] |Mice, Inbred Strains [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |T-Lymphocytes, Helper-Inducer/*immunology [MESH]The coinhibitory receptor CTLA-4 controls B cell responses by modulati(epmc).pdf DeepDyve Pubget Overpricing