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10.1098/rsta.2013.0392 http://scihub22266oqcxt.onion/10.1098/rsta.2013.0392 C4308986!4308986!25624511     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Philos+Trans+A+Math+Phys+Eng+Sci 2015 ; 373 (2036): ä Nephropedia Template TP {{tp|p=25624511|t=2015. Understanding the structural basis for controlling chromosome division |pdf=|usr=}}{{25624511}} gab.com Text Understanding the structural basis for controlling chromosome division JO: Philos Trans A Math Phys Eng Sci http://www.kidney.de/pget.php?&tw=1&pmid=25624511 #FOAvip The process of chromosome division, termed mitosis, involves a complex sequence of events that is tightly controlled to ensure that the faithful segregation of duplicated chromosomes is coordinated with each cell division cycle. The large macromolecular complex responsible for regulating this process is the anaphase-promoting complex or cyclosome (APC/C). In humans, the APC/C is assembled from 20 subunits derived from 15 different proteins. The APC/C functions to ubiquitinate cell cycle regulatory proteins, thereby targeting them for destruction by the proteasome. This review describes our research aimed at understanding the structure and mechanism of the APC/C. We have determined the crystal structures of individual subunits and subcomplexes that provide atomic models to interpret density maps of the whole complex derived from single particle cryo-electron microscopy. With this information, we are generating pseudo-atomic models of functional states of the APC/C that provide insights into its overall architecture and mechanisms of substrate recognition, catalysis and regulation by inhibitory complexes. Twit Text FOAVip Understanding the structural basis for controlling chromosome division ????Philos Trans A Math Phys Eng Sci http://www.kidney.de/pget.php?&tw=1&pmid=25624511 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25624511 #FOAvip English Wikipedia <ref>{{Cite pmid|25624511}}</ref> Understanding the structural basis for controlling chromosome division #MMPMID25624511 Barford D Philos Trans A Math Phys Eng Sci 2015[Mar]; 373 (2036): ä PMID25624511show ga The process of chromosome division, termed mitosis, involves a complex sequence of events that is tightly controlled to ensure that the faithful segregation of duplicated chromosomes is coordinated with each cell division cycle. The large macromolecular complex responsible for regulating this process is the anaphase-promoting complex or cyclosome (APC/C). In humans, the APC/C is assembled from 20 subunits derived from 15 different proteins. The APC/C functions to ubiquitinate cell cycle regulatory proteins, thereby targeting them for destruction by the proteasome. This review describes our research aimed at understanding the structure and mechanism of the APC/C. We have determined the crystal structures of individual subunits and subcomplexes that provide atomic models to interpret density maps of the whole complex derived from single particle cryo-electron microscopy. With this information, we are generating pseudo-atomic models of functional states of the APC/C that provide insights into its overall architecture and mechanisms of substrate recognition, catalysis and regulation by inhibitory complexes. äUnderstanding the structural basis for controlling chromosome division(epmc).pdf DeepDyve Pubget Overpricing