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10.1002/art.38823 http://scihub22266oqcxt.onion/10.1002/art.38823 C4308556!4308556!25155712     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arthritis+Rheumatol 2014 ; 66 (12): 3505-10 Nephropedia Template TP {{tp|p=25155712|t=2014. Lumbar spinal stenosis is a highly genetic condition partly mediated by disc degeneration |pdf=|usr=}}{{25155712}} gab.com Text Lumbar spinal stenosis is a highly genetic condition partly mediated by disc degeneration JO: Arthritis Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=25155712 #FOAvip Objectives: Lumbar spinal stenosis is one of the most commonly diagnosed spinal disorders in older adults. Although the pathophysiology of the clinical syndrome is not well understood, a narrow central canal or intervertebral foramen is an essential or defining feature. The aim of the present study was to estimate the magnitude of genetic versus environmental influences on central lumbar spinal stenosis, and investigate disc degeneration and stature or bone development as possible genetic pathways. Methods: A classic twin study with multivariate analyses considering lumbar level and other covariates was conducted. The study sample comprised 598 male twins (147 monozygotic and 152 dizygotic pairs), 35-70 years of age, from the population-based Finnish Twin Cohort. Primary phenotypes were central lumbar stenosis assessed qualitatively on MRI and quantitatively measured dural sac cross-sectional area. Additional phenotypes to examine possible genetic pathways included disc bulging and standing height, as an indicator of overall skeletal size or development. Results: The heritability estimate (h2) for qualitatively assessed central lumbar spinal stenosis on MRI was 67% (95%CI: 56.8-74.5). The broad sense heritability estimate for dural sac cross-sectional area was 81.2% (95%CI: 74.5 ? 86.1%), with a similar magnitude of genetic influences across lumbar levels (h2=72.4-75.6). The additive genetic correlation of quantitatively assessed stenosis and disc bulging was extremely high. There was no indication of shared genetic influences between stenosis and stature. Conclusion: Central lumbar spinal stenosis and associated dural sac dimensions are highly genetic, and disc degeneration (bulging) appears to be one pathway through which genes influence spinal stenosis. Twit Text FOAVip Lumbar spinal stenosis is a highly genetic condition partly mediated by disc degeneration ????Arthritis Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=25155712 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25155712 #FOAvip English Wikipedia <ref>{{Cite pmid|25155712}}</ref> Lumbar spinal stenosis is a highly genetic condition partly mediated by disc degeneration #MMPMID25155712 Battié MC; Ortega-Alonso A; Niemelainen R; Gill K; Levalahti E; Videman T; Kaprio J Arthritis Rheumatol 2014[Dec]; 66 (12): 3505-10 PMID25155712show ga Objectives: Lumbar spinal stenosis is one of the most commonly diagnosed spinal disorders in older adults. Although the pathophysiology of the clinical syndrome is not well understood, a narrow central canal or intervertebral foramen is an essential or defining feature. The aim of the present study was to estimate the magnitude of genetic versus environmental influences on central lumbar spinal stenosis, and investigate disc degeneration and stature or bone development as possible genetic pathways. Methods: A classic twin study with multivariate analyses considering lumbar level and other covariates was conducted. The study sample comprised 598 male twins (147 monozygotic and 152 dizygotic pairs), 35-70 years of age, from the population-based Finnish Twin Cohort. Primary phenotypes were central lumbar stenosis assessed qualitatively on MRI and quantitatively measured dural sac cross-sectional area. Additional phenotypes to examine possible genetic pathways included disc bulging and standing height, as an indicator of overall skeletal size or development. Results: The heritability estimate (h2) for qualitatively assessed central lumbar spinal stenosis on MRI was 67% (95%CI: 56.8-74.5). The broad sense heritability estimate for dural sac cross-sectional area was 81.2% (95%CI: 74.5 ? 86.1%), with a similar magnitude of genetic influences across lumbar levels (h2=72.4-75.6). The additive genetic correlation of quantitatively assessed stenosis and disc bulging was extremely high. There was no indication of shared genetic influences between stenosis and stature. Conclusion: Central lumbar spinal stenosis and associated dural sac dimensions are highly genetic, and disc degeneration (bulging) appears to be one pathway through which genes influence spinal stenosis. äLumbar spinal stenosis is a highly genetic condition partly mediated b(epmc).pdf DeepDyve Pubget Overpricing