Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.4049/jimmunol.1402051 http://scihub22266oqcxt.onion/10.4049/jimmunol.1402051 C4308418!4308418 !25320273     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25320273 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25320273 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2014 ; 193 (10 ): 4779-82 Nephropedia Template TP {{tp|p=25320273 |t=2014. Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation |pdf=|usr=}}{{25320273 }} gab.com Text Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25320273 #FOAvip Stimulator of IFN genes (STING) is a cytoplasmic innate immune sensor for cyclic dinucleotides that also serves a dual role as an adaptor molecule for a number of intracellular DNA receptors. Although STING has important functions in the host defense against pathogens and autoimmune diseases, its physiological role in cancer is unknown. In this study, we show that STING-deficient mice are highly susceptible to colitis-associated colorectal cancer. Colons of STING-deficient mice exhibit significant intestinal damage and overt proliferation during early stages of tumorigenesis. Moreover, STING-deficient mice fail to restrict activation of the NF-?B- and STAT3-signaling pathways, which leads to increased levels of the proinflammatory cytokines IL-6 and KC. Therefore, our results identified an unexpected and important role for STING in mediating protection against colorectal tumorigenesis. Twit Text FOAVip Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25320273 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25320273 #FOAvip English Wikipedia <ref>{{Cite pmid|25320273 }}</ref> Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation #MMPMID25320273 Zhu Q ; Man SM ; Gurung P ; Liu Z ; Vogel P ; Lamkanfi M ; Kanneganti TD J Immunol 2014[Nov]; 193 (10 ): 4779-82 PMID25320273 show ga Stimulator of IFN genes (STING) is a cytoplasmic innate immune sensor for cyclic dinucleotides that also serves a dual role as an adaptor molecule for a number of intracellular DNA receptors. Although STING has important functions in the host defense against pathogens and autoimmune diseases, its physiological role in cancer is unknown. In this study, we show that STING-deficient mice are highly susceptible to colitis-associated colorectal cancer. Colons of STING-deficient mice exhibit significant intestinal damage and overt proliferation during early stages of tumorigenesis. Moreover, STING-deficient mice fail to restrict activation of the NF-?B- and STAT3-signaling pathways, which leads to increased levels of the proinflammatory cytokines IL-6 and KC. Therefore, our results identified an unexpected and important role for STING in mediating protection against colorectal tumorigenesis. |Animals [MESH] |Chemokine CXCL1/genetics/immunology [MESH] |Colitis/complications/genetics/*immunology/pathology [MESH] |Colon/immunology/*pathology [MESH] |Colorectal Neoplasms/etiology/genetics/*immunology/pathology [MESH] |Gene Expression Regulation/*immunology [MESH] |Interleukin-6/genetics/immunology [MESH] |Membrane Proteins/deficiency/genetics/*immunology [MESH] |Mice [MESH] |Mice, Knockout [MESH] |NF-kappa B/genetics/immunology [MESH] |STAT3 Transcription Factor/genetics/immunology [MESH]Cutting edge: STING mediates protection against colorectal tumorigenes(epmc).pdf DeepDyve Pubget Overpricing