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10.4049/jimmunol.1302565 http://scihub22266oqcxt.onion/10.4049/jimmunol.1302565 C4305442!4305442 !25225666     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25225666 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2014 ; 193 (8 ): 4169-77 Nephropedia Template TP {{tp|p=25225666 |t=2014. Prolonged antigen presentation following an acute virus infection requires direct and then cross-presentation |pdf=|usr=}}{{25225666 }} gab.com Text Prolonged antigen presentation following an acute virus infection requires direct and then cross-presentation JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25225666 #FOAvip Antiviral CD8(+) T cell recognition of MHC class I-peptide complexes on the surface of professional APCs is a requisite step in an effective immune response following many potentially lethal infections. Although MHC class I-peptide production is thought to be closely linked to the continued presence of virus, several studies have shown that the persistence of Ag presentation occurs for an extended period of time following the clearance of RNA viruses. However, the mechanism responsible for Ag presentation persistence following viral clearance was unknown until now. In this study, we used a recombinant DNA virus expressing different forms of a model Ag to study the mechanism of prolonged Ag presentation in mice. We determined that the persistence of Ag presentation consists of three distinct mechanistic phases, as follows: ongoing viral replication, persistence of virally infected cells, and cross-presentation of Ag. These data will allow manipulation of the form of Ag contained within viral vectors to produce the most effective and protective CD8(+) T cell response to be generated following vaccination. Twit Text FOAVip Prolonged antigen presentation following an acute virus infection requires direct and then cross-presentation ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25225666 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25225666 #FOAvip English Wikipedia <ref>{{Cite pmid|25225666 }}</ref> Prolonged antigen presentation following an acute virus infection requires direct and then cross-presentation #MMPMID25225666 Heipertz EL ; Davies ML ; Lin E ; Norbury CC J Immunol 2014[Oct]; 193 (8 ): 4169-77 PMID25225666 show ga Antiviral CD8(+) T cell recognition of MHC class I-peptide complexes on the surface of professional APCs is a requisite step in an effective immune response following many potentially lethal infections. Although MHC class I-peptide production is thought to be closely linked to the continued presence of virus, several studies have shown that the persistence of Ag presentation occurs for an extended period of time following the clearance of RNA viruses. However, the mechanism responsible for Ag presentation persistence following viral clearance was unknown until now. In this study, we used a recombinant DNA virus expressing different forms of a model Ag to study the mechanism of prolonged Ag presentation in mice. We determined that the persistence of Ag presentation consists of three distinct mechanistic phases, as follows: ongoing viral replication, persistence of virally infected cells, and cross-presentation of Ag. These data will allow manipulation of the form of Ag contained within viral vectors to produce the most effective and protective CD8(+) T cell response to be generated following vaccination. |Animals [MESH] |Antigen Presentation/*immunology [MESH] |Antigen-Presenting Cells/*immunology [MESH] |Antigens, Viral/*immunology [MESH] |CD8-Positive T-Lymphocytes/*immunology [MESH] |Cells, Cultured [MESH] |Cross-Priming/immunology [MESH] |Histocompatibility Antigens Class I/immunology [MESH] |Lymphocyte Activation/immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Ovalbumin/immunology [MESH] |Recombinant Proteins/immunology [MESH] |Vaccinia virus/genetics/*immunology [MESH]Prolonged antigen presentation following an acute virus infection requ(epmc).pdf DeepDyve Pubget Overpricing