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10.1038/gene.2014.57 http://scihub22266oqcxt.onion/10.1038/gene.2014.57 C4305028!4305028!25338677     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25338677&cmd=llinks): Failed to open stream: HTTP request failed! 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Genetic Analysis of the Pathogenic Molecular Sub-phenotype Interferon Alpha Identifies Multiple Novel Loci Involved in Systemic Lupus Erythematosus |pdf=|usr=}}{{25338677}} gab.com Text Genetic Analysis of the Pathogenic Molecular Sub-phenotype Interferon Alpha Identifies Multiple Novel Loci Involved in Systemic Lupus Erythematosus JO: Genes Immun http://www.kidney.de/pget.php?&tw=1&pmid=25338677 #FOAvip Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disorder characterized by inflammation of multiple organ systems and dysregulated interferon responses. SLE is both genetically and phenotypically heterogeneous, greatly reducing the power of case-control studies in SLE. Elevated circulating interferon alpha (IFN-?) is a stable, heritable trait in SLE, which has been implicated in primary disease pathogenesis. 40?50% of patients have high IFN-?, and high levels correspond with clinical differences. To study genetic heterogeneity in SLE, we performed a case-case study comparing patients with high vs. low IFN-? in over 1550 SLE cases, including GWAS and replication cohorts. In meta-analysis, the top associations in European ancestry were PRKG1 rs7897633 (PMeta=2.75 × 10?8) and PNP rs1049564 (PMeta=1.24 × 10?7). We also found evidence for cross-ancestral background associations with the ANKRD44 and PLEKHF2 loci. These loci have not been previously identified in case-control SLE genetic studies. Bioinformatic analyses implicated these loci functionally in dendritic cells and natural killer cells, both of which are involved in IFN-? production in SLE. As case-control studies of heterogeneous diseases reach a limit of feasibility with respect to subject number and detectable effect size, the study of informative pathogenic subphenotypes becomes an attractive strategy for genetic discovery in complex disease. Twit Text FOAVip Genetic Analysis of the Pathogenic Molecular Sub-phenotype Interferon Alpha Identifies Multiple Novel Loci Involved in Systemic Lupus Erythematosus ????Genes Immun http://www.kidney.de/pget.php?&tw=1&pmid=25338677 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25338677 #FOAvip English Wikipedia <ref>{{Cite pmid|25338677}}</ref> Genetic Analysis of the Pathogenic Molecular Sub-phenotype Interferon Alpha Identifies Multiple Novel Loci Involved in Systemic Lupus Erythematosus #MMPMID25338677 Kariuki SN; Ghodke-Puranik Y; Dorschner JM; Chrabot BS; Kelly JA; Tsao BP; Kimberly RP; Alarcón-Riquelme ME; Jacob CO; Criswell LA; Sivils KL; Langefeld CD; Harley JB; Skol AD; Niewold TB Genes Immun 2015[Jan]; 16 (1): 15-23 PMID25338677show ga Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disorder characterized by inflammation of multiple organ systems and dysregulated interferon responses. SLE is both genetically and phenotypically heterogeneous, greatly reducing the power of case-control studies in SLE. Elevated circulating interferon alpha (IFN-?) is a stable, heritable trait in SLE, which has been implicated in primary disease pathogenesis. 40?50% of patients have high IFN-?, and high levels correspond with clinical differences. To study genetic heterogeneity in SLE, we performed a case-case study comparing patients with high vs. low IFN-? in over 1550 SLE cases, including GWAS and replication cohorts. In meta-analysis, the top associations in European ancestry were PRKG1 rs7897633 (PMeta=2.75 × 10?8) and PNP rs1049564 (PMeta=1.24 × 10?7). We also found evidence for cross-ancestral background associations with the ANKRD44 and PLEKHF2 loci. These loci have not been previously identified in case-control SLE genetic studies. Bioinformatic analyses implicated these loci functionally in dendritic cells and natural killer cells, both of which are involved in IFN-? production in SLE. As case-control studies of heterogeneous diseases reach a limit of feasibility with respect to subject number and detectable effect size, the study of informative pathogenic subphenotypes becomes an attractive strategy for genetic discovery in complex disease. äGenetic Analysis of the Pathogenic Molecular Sub-phenotype Interferon (epmc).pdf DeepDyve Pubget Overpricing