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10.1016/j.cell.2014.08.042 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.08.042 C4304671!4304671!25284152     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2014 ; 159 (2): 333-45 Nephropedia Template TP {{tp|p=25284152|t=2014. Co-receptor scanning by the T-cell receptor provides a mechanism for T cell tolerance |pdf=|usr=}}{{25284152}} gab.com Text Co-receptor scanning by the T-cell receptor provides a mechanism for T cell tolerance JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=25284152 #FOAvip In the thymus, high affinity, self-reactive thymocytes are eliminated from the pool of developing T cells, generating central tolerance. Here, we investigate how developing T cells measure self-antigen affinity. We show that very few CD4 or CD8 coreceptor molecules are coupled with the signal-initiating kinase, Lck. To initiate signaling, an antigen engaged T cell receptor (TCR) scans multiple coreceptor molecules to find one that is coupled to Lck. Coreceptor scanning is the first and rate-limiting step in a kinetic proofreading chain of events that eventually leads to TCR triggering and negative selection. MHCII-restricted TCRs require a shorter antigen dwell time (~0.2s) to initiate negative selection compared to MHCI restricted TCRs (~0.9s) because more CD4 coreceptors are Lck-loaded compared to CD8. Based on experimental data and mathematical analysis, we generated a model (Lck come&stay/signal duration) that accurately predicts the experimentally observed differences in antigen dwell-time thresholds used by MHCI- and MHCII-restricted thymocytes to initiate negative selection and generate self-tolerance. Twit Text FOAVip Co-receptor scanning by the T-cell receptor provides a mechanism for T cell tolerance ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=25284152 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25284152 #FOAvip English Wikipedia <ref>{{Cite pmid|25284152}}</ref> Co-receptor scanning by the T-cell receptor provides a mechanism for T cell tolerance #MMPMID25284152 Stepanek O; Prabhakar AS; Osswald C; King CG; Bulek A; Naeher D; Beaufils-Hugot M; Abanto ML; Galati V; Hausmann B; Lang R; Cole DK; Huseby ES; Sewell AK; Chakraborty AK; Palmer E Cell 2014[Oct]; 159 (2): 333-45 PMID25284152show ga In the thymus, high affinity, self-reactive thymocytes are eliminated from the pool of developing T cells, generating central tolerance. Here, we investigate how developing T cells measure self-antigen affinity. We show that very few CD4 or CD8 coreceptor molecules are coupled with the signal-initiating kinase, Lck. To initiate signaling, an antigen engaged T cell receptor (TCR) scans multiple coreceptor molecules to find one that is coupled to Lck. Coreceptor scanning is the first and rate-limiting step in a kinetic proofreading chain of events that eventually leads to TCR triggering and negative selection. MHCII-restricted TCRs require a shorter antigen dwell time (~0.2s) to initiate negative selection compared to MHCI restricted TCRs (~0.9s) because more CD4 coreceptors are Lck-loaded compared to CD8. Based on experimental data and mathematical analysis, we generated a model (Lck come&stay/signal duration) that accurately predicts the experimentally observed differences in antigen dwell-time thresholds used by MHCI- and MHCII-restricted thymocytes to initiate negative selection and generate self-tolerance. äCo-receptor scanning by the T-cell receptor provides a mechanism for T(epmc).pdf DeepDyve Pubget Overpricing