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10.1038/ncomms6779 http://scihub22266oqcxt.onion/10.1038/ncomms6779 C4304414!4304414!25609235     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): 5779 Nephropedia Template TP {{tp|p=25609235|t=2015. Autophagy enhances NF?B activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity |pdf=|usr=}}{{25609235}} gab.com Text Autophagy enhances NF B activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25609235 #FOAvip Immune responses must be well restrained in a steady state to avoid excessive inflammation. However, such restraints are quickly removed to exert anti-microbial responses. Here, we report a role of autophagy in an early host anti-fungal response by enhancing NF?B activity through A20 sequestration. Enhancement of NF?B activation is achieved by autophagic depletion of A20, an NF?B inhibitor, in F4/80hi macrophages in the spleen, peritoneum, and kidney. We show that p62, an autophagic adaptor protein, captures A20 to sequester it in the autophagosome. This allows the macrophages to release chemokines to recruit neutrophils. Indeed, mice lacking autophagy in myeloid cells show higher susceptibility to Candida albicans infection due to impairment in neutrophil recruitment. Thus, at least in the specific aforementioned tissues, autophagy appears to break A20-dependent suppression in F4/80hi macrophages, which express abundant A20 and contribute to the initiation of efficient innate immune responses. Twit Text FOAVip Autophagy enhances NF B activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25609235 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25609235 #FOAvip English Wikipedia <ref>{{Cite pmid|25609235}}</ref> Autophagy enhances NF?B activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity #MMPMID25609235 Kanayama M; Inoue M; Danzaki K; Hammer G; He YW; Shinohara ML Nat Commun 2015[]; 6 (ä): 5779 PMID25609235show ga Immune responses must be well restrained in a steady state to avoid excessive inflammation. However, such restraints are quickly removed to exert anti-microbial responses. Here, we report a role of autophagy in an early host anti-fungal response by enhancing NF?B activity through A20 sequestration. Enhancement of NF?B activation is achieved by autophagic depletion of A20, an NF?B inhibitor, in F4/80hi macrophages in the spleen, peritoneum, and kidney. We show that p62, an autophagic adaptor protein, captures A20 to sequester it in the autophagosome. This allows the macrophages to release chemokines to recruit neutrophils. Indeed, mice lacking autophagy in myeloid cells show higher susceptibility to Candida albicans infection due to impairment in neutrophil recruitment. Thus, at least in the specific aforementioned tissues, autophagy appears to break A20-dependent suppression in F4/80hi macrophages, which express abundant A20 and contribute to the initiation of efficient innate immune responses. äAutophagy enhances NF?B activity in specific tissue macrophages by seq(epmc).pdf DeepDyve Pubget Overpricing