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10.1038/ncomms7131 http://scihub22266oqcxt.onion/10.1038/ncomms7131 C4302761!4302761 !25607885     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25607885 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2015 ; 6 (ä): 6131 Nephropedia Template TP {{tp|p=25607885 |t=2015. IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis |pdf=|usr=}}{{25607885 }} gab.com Text IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25607885 #FOAvip Polymorphisms attenuating IL-10 signalling confer genetic risk for inflammatory bowel disease. Yet, how IL-10 prevents mucosal autoinflammation is incompletely understood. We demonstrate using lineage-specific deletions of IL-10R? that IL-10 acts primarily through macrophages to limit colitis. Colitis depends on IL-6 to support pathologic Th17 cell generation in wild-type mice. However, specific ablation of macrophage IL-10R? provokes excessive IL-1? production that overrides Th17 IL-6 dependency, amplifying the colonic Th17 response and disease severity. IL-10 not only inhibits pro-IL-1? production transcriptionally in macrophages, but suppresses caspase-1 activation and caspase-1-dependent maturation of pro-IL-1? to IL-1?. Therefore, lineage-specific effects of IL-10 skew the cytokine dependency of Th17 cell development required for colitis pathogenesis. Coordinated interventions may be needed to fully suppress Th17-mediated immunopathology. Twit Text FOAVip IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25607885 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25607885 #FOAvip English Wikipedia <ref>{{Cite pmid|25607885 }}</ref> IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis #MMPMID25607885 Li B ; Gurung P ; Malireddi RK ; Vogel P ; Kanneganti TD ; Geiger TL Nat Commun 2015[Jan]; 6 (ä): 6131 PMID25607885 show ga Polymorphisms attenuating IL-10 signalling confer genetic risk for inflammatory bowel disease. Yet, how IL-10 prevents mucosal autoinflammation is incompletely understood. We demonstrate using lineage-specific deletions of IL-10R? that IL-10 acts primarily through macrophages to limit colitis. Colitis depends on IL-6 to support pathologic Th17 cell generation in wild-type mice. However, specific ablation of macrophage IL-10R? provokes excessive IL-1? production that overrides Th17 IL-6 dependency, amplifying the colonic Th17 response and disease severity. IL-10 not only inhibits pro-IL-1? production transcriptionally in macrophages, but suppresses caspase-1 activation and caspase-1-dependent maturation of pro-IL-1? to IL-1?. Therefore, lineage-specific effects of IL-10 skew the cytokine dependency of Th17 cell development required for colitis pathogenesis. Coordinated interventions may be needed to fully suppress Th17-mediated immunopathology. |Animals [MESH] |Caspase 1/metabolism [MESH] |Cell Lineage [MESH] |Colitis/genetics/metabolism [MESH] |Colon/metabolism [MESH] |Cytokines/metabolism [MESH] |Forkhead Transcription Factors/metabolism [MESH] |Homeodomain Proteins/genetics [MESH] |Inflammasomes [MESH] |Inflammation [MESH] |Inflammatory Bowel Diseases/metabolism [MESH] |Interleukin 1 Receptor Antagonist Protein/genetics [MESH] |Interleukin-10/*metabolism [MESH] |Interleukin-1beta/metabolism [MESH] |Macrophages/*metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Risk [MESH] |Signal Transduction [MESH] |Th17 Cells/*metabolism [MESH]IL-10 engages macrophages to shift Th17 cytokine dependency and pathog(epmc).pdf DeepDyve Pubget Overpricing