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10.1021/bi500707c http://scihub22266oqcxt.onion/10.1021/bi500707c C4302021!4302021!25303020     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochemistry 2015 ; 54 (2): 124-33 Nephropedia Template TP {{tp|p=25303020|t=2015. Circadian Genomics Reveal a Role for Post-transcriptional Regulation in Mammals |pdf=|usr=}}{{25303020}} gab.com Text Circadian Genomics Reveal a Role for Post-transcriptional Regulation in Mammals JO: Biochemistry http://www.kidney.de/pget.php?&tw=1&pmid=25303020 #FOAvip To maintain daily cycles, the circadian clock must tightly regulate the rhythms of thousands of mRNAs and proteins with the correct period, phase, and amplitude to ultimately drive the wide range of rhythmic biological processes. Recent genomic approaches have revolutionized our view of circadian gene expression and highlighted the importance of post-transcriptional regulation in driving mRNA rhythmicity. Even after transcripts are made from DNA, subsequent processing and regulatory steps determine when, where, and how much protein will be generated. These post-transcriptional regulatory mechanisms can add flexibility to overall gene expression and alter protein levels rapidly without requiring transcript synthesis and are therefore beneficial for cells; however, the extent to which circadian post-transcriptional mechanisms contribute to rhythmic profiles throughout the genome and the mechanisms involved have not been fully elucidated. In this review, we will summarize how circadian genomics have revealed new insights into rhythmic post-transcriptional regulation in mammals and discuss potential implications of such regulation in controlling many circadian-driven physiologies. Twit Text FOAVip Circadian Genomics Reveal a Role for Post-transcriptional Regulation in Mammals ????Biochemistry http://www.kidney.de/pget.php?&tw=1&pmid=25303020 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25303020 #FOAvip English Wikipedia <ref>{{Cite pmid|25303020}}</ref> Circadian Genomics Reveal a Role for Post-transcriptional Regulation in Mammals #MMPMID25303020 Kojima S; Green CB Biochemistry 2015[Jan]; 54 (2): 124-33 PMID25303020show ga To maintain daily cycles, the circadian clock must tightly regulate the rhythms of thousands of mRNAs and proteins with the correct period, phase, and amplitude to ultimately drive the wide range of rhythmic biological processes. Recent genomic approaches have revolutionized our view of circadian gene expression and highlighted the importance of post-transcriptional regulation in driving mRNA rhythmicity. Even after transcripts are made from DNA, subsequent processing and regulatory steps determine when, where, and how much protein will be generated. These post-transcriptional regulatory mechanisms can add flexibility to overall gene expression and alter protein levels rapidly without requiring transcript synthesis and are therefore beneficial for cells; however, the extent to which circadian post-transcriptional mechanisms contribute to rhythmic profiles throughout the genome and the mechanisms involved have not been fully elucidated. In this review, we will summarize how circadian genomics have revealed new insights into rhythmic post-transcriptional regulation in mammals and discuss potential implications of such regulation in controlling many circadian-driven physiologies. äCircadian Genomics Reveal a Role for Post-transcriptional Regulation i(epmc).pdf DeepDyve Pubget Overpricing