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10.1093/ndt/gfu280 http://scihub22266oqcxt.onion/10.1093/ndt/gfu280 C4301831!4301831!25170095     free     free     free       Nephrol+Dial+Transplant 2015 ; 30 (6): 910-7 Nephropedia Template TP {{tp|p=25170095|t=2015. microRNAs in Kidney Transplantation |pdf=|usr=}}{{25170095}} gab.com Text microRNAs in Kidney Transplantation JO: Nephrol Dial Transplant http://www.kidney.de/pget.php?&tw=1&pmid=25170095 #FOAvip The discovery of novel classes of non-coding RNAs (ncRNAs) has revolutionized medicine. Long time thought as a mere cellular housekeeper, surprising functions have recently been uncovered. microRNAs (miRNAs), a representative of the class of short ncRNAs, play a fundamental role in the control of DNA and protein biosynthesis and activity as well as pathology. Currently miRNAs are investigated as diagnostic and prognostic markers and potentially therapeutic targets in kidney transplantation for such indolent processes as ischemia-reperfusion injury, humoral rejection or viral infections. It is realistic to believe that monitoring of renal allograft recipients in the future will include genome-wide miRNA profiling of biological fluids. Based on these individual profiles an informed decision on therapeutic consequences will be possible. First success with a specific suppression of miRNAs by antisense oligonucleotides was achieved in experimental studies of reperfusion injury and humoral rejection. Proof of this concept in men comes from studies in such indolent viral infections as Ebola and hepatitis C where anti-miR therapy led to sustained viral clearance.In this review we summarize the basis of the recent non-coding RNA revolution and its implication for kidney transplantation. Twit Text FOAVip microRNAs in Kidney Transplantation ????Nephrol Dial Transplant http://www.kidney.de/pget.php?&tw=1&pmid=25170095 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25170095 #FOAvip English Wikipedia <ref>{{Cite pmid|25170095}}</ref> microRNAs in Kidney Transplantation #MMPMID25170095 Wilflingseder J; Reindl-Schwaighofer R; Sunzenauer J; Kainz A; Heinzel A; Mayer B; Oberbauer R Nephrol Dial Transplant 2015[Jun]; 30 (6): 910-7 PMID25170095show ga The discovery of novel classes of non-coding RNAs (ncRNAs) has revolutionized medicine. Long time thought as a mere cellular housekeeper, surprising functions have recently been uncovered. microRNAs (miRNAs), a representative of the class of short ncRNAs, play a fundamental role in the control of DNA and protein biosynthesis and activity as well as pathology. Currently miRNAs are investigated as diagnostic and prognostic markers and potentially therapeutic targets in kidney transplantation for such indolent processes as ischemia-reperfusion injury, humoral rejection or viral infections. It is realistic to believe that monitoring of renal allograft recipients in the future will include genome-wide miRNA profiling of biological fluids. Based on these individual profiles an informed decision on therapeutic consequences will be possible. First success with a specific suppression of miRNAs by antisense oligonucleotides was achieved in experimental studies of reperfusion injury and humoral rejection. Proof of this concept in men comes from studies in such indolent viral infections as Ebola and hepatitis C where anti-miR therapy led to sustained viral clearance.In this review we summarize the basis of the recent non-coding RNA revolution and its implication for kidney transplantation. ämicroRNAs in Kidney Transplantation (epmc).pdf DeepDyve Pubget Overpricing