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10.1128/JVI.02897-14 http://scihub22266oqcxt.onion/10.1128/JVI.02897-14 C4301146!4301146!25355870     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Virol 2015 ; 89 (1): 730-42 Nephropedia Template TP {{tp|p=25355870|t=2015. Impact and Regulation of Lambda Interferon Response in Human Metapneumovirus Infection |pdf=|usr=}}{{25355870}} gab.com Text Impact and Regulation of Lambda Interferon Response in Human Metapneumovirus Infection JO: J Virol http://www.kidney.de/pget.php?&tw=1&pmid=25355870 #FOAvip Human metapneumovirus (hMPV) is a respiratory paramyxovirus that is distributed worldwide and induces significant airway morbidity. Despite the relevance of hMPV as a pathogen, many aspects of the immune response to this virus are still largely unknown. In this report, we focus on the antiviral immune response, which is critical for viral clearance and disease resolution. Using in vitro and in vivo systems, we show that hMPV is able to induce expression of lambda interferon 1 (IFN-?1), IFN-?2, IFN-?3, and IFN-?4. The induction of IFN-? expression by hMPV was dependent on interferon regulatory factor 7 (IRF-7) expression but not on IRF-3 expression. Treatment of hMPV-infected mice with IFN-? reduced the disease severity, lung viral titer, and inflammatory response in the lung. Moreover, the IFN-? response induced by the virus was regulated by the expression of the hMPV G protein. These results show that type III interferons (IFN-?s) play a critical protective role in hMPV infection.IMPORTANCE Human metapneumovirus (hMPV) is a pathogen of worldwide importance. Despite the relevance of hMPV as a pathogen, critical aspects of the immune response induced by this virus remain unidentified. Interferons (IFNs), including IFN-?, the newest addition to the interferon family, constitute an indispensable part of the innate immune response. Here, we demonstrated that IFN-? exhibited a protective role in hMPV infection in vitro and in an experimental mouse model of infection. Twit Text FOAVip Impact and Regulation of Lambda Interferon Response in Human Metapneumovirus Infection ????J Virol http://www.kidney.de/pget.php?&tw=1&pmid=25355870 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25355870 #FOAvip English Wikipedia <ref>{{Cite pmid|25355870}}</ref> Impact and Regulation of Lambda Interferon Response in Human Metapneumovirus Infection #MMPMID25355870 Baños-Lara MDR; Harvey L; Mendoza A; Simms D; Chouljenko VN; Wakamatsu N; Kousoulas KG; Guerrero-Plata A J Virol 2015[Jan]; 89 (1): 730-42 PMID25355870show ga Human metapneumovirus (hMPV) is a respiratory paramyxovirus that is distributed worldwide and induces significant airway morbidity. Despite the relevance of hMPV as a pathogen, many aspects of the immune response to this virus are still largely unknown. In this report, we focus on the antiviral immune response, which is critical for viral clearance and disease resolution. Using in vitro and in vivo systems, we show that hMPV is able to induce expression of lambda interferon 1 (IFN-?1), IFN-?2, IFN-?3, and IFN-?4. The induction of IFN-? expression by hMPV was dependent on interferon regulatory factor 7 (IRF-7) expression but not on IRF-3 expression. Treatment of hMPV-infected mice with IFN-? reduced the disease severity, lung viral titer, and inflammatory response in the lung. Moreover, the IFN-? response induced by the virus was regulated by the expression of the hMPV G protein. These results show that type III interferons (IFN-?s) play a critical protective role in hMPV infection.IMPORTANCE Human metapneumovirus (hMPV) is a pathogen of worldwide importance. Despite the relevance of hMPV as a pathogen, critical aspects of the immune response induced by this virus remain unidentified. Interferons (IFNs), including IFN-?, the newest addition to the interferon family, constitute an indispensable part of the innate immune response. Here, we demonstrated that IFN-? exhibited a protective role in hMPV infection in vitro and in an experimental mouse model of infection. äImpact and Regulation of Lambda Interferon Response in Human Metapneum(epmc).pdf DeepDyve Pubget Overpricing