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10.1164/rccm.201407-1287OC http://scihub22266oqcxt.onion/10.1164/rccm.201407-1287OC C4299649!4299649!25347450     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Respir+Crit+Care+Med 2014 ; 190 (12): 1395-401 Nephropedia Template TP {{tp|p=25347450|t=2014. Circulating Fibrocytes as Biomarker of Prognosis in Hermansky-Pudlak Syndrome |pdf=|usr=}}{{25347450}} gab.com Text Circulating Fibrocytes as Biomarker of Prognosis in Hermansky-Pudlak Syndrome JO: Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=25347450 #FOAvip Rationale: The rate of progression of most interstitial lung diseases (ILD) is unpredictable. Fibrocytes are circulating bone marrow?derived cells that have been implicated in the pathogenesis of lung fibrosis. Hermansky-Pudlak syndrome (HPS), a genetic cause of ILD in early adulthood, allows for study of biomarkers of ILD in a homogeneous population at near-certain risk of developing fibrotic lung disease.Objectives: To test the hypothesis that, in subjects with HPS, the number or phenotype of circulating fibrocytes predicts progression and outcome of ILD.Methods: We measured circulating fibrocyte counts and chemokine levels in a cohort of subjects with HPS and healthy control subjects and correlated the results to disease outcome.Measurements and Main Results: In a cross-sectional analysis, peripheral blood fibrocyte concentrations were markedly elevated in a subset of subjects with HPS who had ILD but not subjects without lung disease or normal control subjects. The blood concentration of fibrocytes expressing the chemokine receptor CXCR4 correlated significantly with the plasma concentration of the CXCR4 ligand, CXCL12. In a longitudinal study, we found marked episodic elevations in circulating fibrocyte counts over a median follow-up period of 614 days. Elevations in both maximal values and final values of peripheral blood CXCR4+ fibrocyte concentration were strongly associated with death from ILD.Conclusions: CXCR4+ fibrocyte concentration may be useful as a biomarker for outcome of ILD in subjects with HPS. Twit Text FOAVip Circulating Fibrocytes as Biomarker of Prognosis in Hermansky-Pudlak Syndrome ????Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=25347450 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25347450 #FOAvip English Wikipedia <ref>{{Cite pmid|25347450}}</ref> Circulating Fibrocytes as Biomarker of Prognosis in Hermansky-Pudlak Syndrome #MMPMID25347450 Trimble A; Gochuico BR; Markello TC; Fischer R; Gahl WA; Lee JK; Kim Y; Burdick MD; Strieter RM; Mehrad B Am J Respir Crit Care Med 2014[Dec]; 190 (12): 1395-401 PMID25347450show ga Rationale: The rate of progression of most interstitial lung diseases (ILD) is unpredictable. Fibrocytes are circulating bone marrow?derived cells that have been implicated in the pathogenesis of lung fibrosis. Hermansky-Pudlak syndrome (HPS), a genetic cause of ILD in early adulthood, allows for study of biomarkers of ILD in a homogeneous population at near-certain risk of developing fibrotic lung disease.Objectives: To test the hypothesis that, in subjects with HPS, the number or phenotype of circulating fibrocytes predicts progression and outcome of ILD.Methods: We measured circulating fibrocyte counts and chemokine levels in a cohort of subjects with HPS and healthy control subjects and correlated the results to disease outcome.Measurements and Main Results: In a cross-sectional analysis, peripheral blood fibrocyte concentrations were markedly elevated in a subset of subjects with HPS who had ILD but not subjects without lung disease or normal control subjects. The blood concentration of fibrocytes expressing the chemokine receptor CXCR4 correlated significantly with the plasma concentration of the CXCR4 ligand, CXCL12. In a longitudinal study, we found marked episodic elevations in circulating fibrocyte counts over a median follow-up period of 614 days. Elevations in both maximal values and final values of peripheral blood CXCR4+ fibrocyte concentration were strongly associated with death from ILD.Conclusions: CXCR4+ fibrocyte concentration may be useful as a biomarker for outcome of ILD in subjects with HPS. äCirculating Fibrocytes as Biomarker of Prognosis in Hermansky-Pudlak S(epmc).pdf DeepDyve Pubget Overpricing