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10.1164/rccm.201403-0601OC http://scihub22266oqcxt.onion/10.1164/rccm.201403-0601OC C4299645!4299645!25390970     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Respir+Crit+Care+Med 2014 ; 190 (12): 1383-94 Nephropedia Template TP {{tp|p=25390970|t=2014. IL-6 Receptor ? Defines Effector Memory CD8+ T Cells Producing Th2 Cytokines and Expanding in Asthma |pdf=|usr=}}{{25390970}} gab.com Text IL-6 Receptor Defines Effector Memory CD8+ T Cells Producing Th2 Cytokines and Expanding in Asthma JO: Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=25390970 #FOAvip Rationale: Cytokine receptors can be markers defining different T-cell subsets and considered as therapeutic targets. The association of IL-6 and IL-6 receptor ? (IL-6R?) with asthma was reported, suggesting their involvement in asthma.Objectives: To determine whether and how IL-6R? defines a distinct effector memory (EM) CD8+ T-cell population in health and disease.Methods: EM CD8+ T cells expressing IL-6R? (IL-6R?high) were identified in human peripheral blood and analyzed for function, gene, and transcription factor expression. The relationship of these cells with asthma was determined using blood and sputum.Measurements and Main Results: A unique population of IL-6R?high EM CD8+ T cells was found in peripheral blood. These cells that potently proliferated, survived, and produced high levels of the Th2-type cytokines IL-5 and IL-13 had increased levels of GATA3 and decreased levels of T-bet and Blimp-1 in comparison with other EM CD8+ T cells. In fact, GATA3 was required for IL-6R? expression. Patients with asthma had an increased frequency of IL-6R?high EM CD8+ T cells in peripheral blood compared with healthy control subjects. Also, IL-6R?high EM CD8+ T cells exclusively produced IL-5 and IL-13 in response to asthma-associated respiratory syncytial virus and bacterial superantigens.Conclusions: Human IL-6R?high EM CD8+ T cells is a unique cell subset that may serve as a reservoir for effector CD8+ T cells, particularly the ones producing Th2-type cytokines, and expand in asthma. Twit Text FOAVip IL-6 Receptor Defines Effector Memory CD8+ T Cells Producing Th2 Cytokines and Expanding in Asthma ????Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=25390970 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25390970 #FOAvip English Wikipedia <ref>{{Cite pmid|25390970}}</ref> IL-6 Receptor ? Defines Effector Memory CD8+ T Cells Producing Th2 Cytokines and Expanding in Asthma #MMPMID25390970 Lee N; You S; Shin MS; Lee WW; Kang KS; Kim SH; Kim WU; Homer RJ; Kang MJ; Montgomery RR; Dela Cruz CS; Shaw AC; Lee PJ; Chupp GL; Hwang D; Kang I Am J Respir Crit Care Med 2014[Dec]; 190 (12): 1383-94 PMID25390970show ga Rationale: Cytokine receptors can be markers defining different T-cell subsets and considered as therapeutic targets. The association of IL-6 and IL-6 receptor ? (IL-6R?) with asthma was reported, suggesting their involvement in asthma.Objectives: To determine whether and how IL-6R? defines a distinct effector memory (EM) CD8+ T-cell population in health and disease.Methods: EM CD8+ T cells expressing IL-6R? (IL-6R?high) were identified in human peripheral blood and analyzed for function, gene, and transcription factor expression. The relationship of these cells with asthma was determined using blood and sputum.Measurements and Main Results: A unique population of IL-6R?high EM CD8+ T cells was found in peripheral blood. These cells that potently proliferated, survived, and produced high levels of the Th2-type cytokines IL-5 and IL-13 had increased levels of GATA3 and decreased levels of T-bet and Blimp-1 in comparison with other EM CD8+ T cells. In fact, GATA3 was required for IL-6R? expression. Patients with asthma had an increased frequency of IL-6R?high EM CD8+ T cells in peripheral blood compared with healthy control subjects. Also, IL-6R?high EM CD8+ T cells exclusively produced IL-5 and IL-13 in response to asthma-associated respiratory syncytial virus and bacterial superantigens.Conclusions: Human IL-6R?high EM CD8+ T cells is a unique cell subset that may serve as a reservoir for effector CD8+ T cells, particularly the ones producing Th2-type cytokines, and expand in asthma. äIL-6 Receptor ? Defines Effector Memory CD8+ T Cells Producing Th2 Cyt(epmc).pdf DeepDyve Pubget Overpricing