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10.1164/rccm.201403-0509PP http://scihub22266oqcxt.onion/10.1164/rccm.201403-0509PP C4299574!4299574 !25090037     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25090037 &cmd=llinks): Failed to open stream: HTTP request failed! 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New therapeutic targets in idiopathic pulmonary fibrosis Aiming to rein in runaway wound-healing responses |pdf=|usr=}}{{25090037 }} gab.com Text New therapeutic targets in idiopathic pulmonary fibrosis Aiming to rein in runaway wound-healing responses JO: Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=25090037 #FOAvip Idiopathic pulmonary fibrosis (IPF) is a devastating disease, with a median survival as short as 3 years from the time of diagnosis and no pharmacological therapies yet approved by the U.S. Food and Drug Administration. To address the great unmet need for effective IPF therapy, a number of new drugs have recently been, or are now being, evaluated in clinical trials. The rationales for most of these therapeutic candidates are based on the current paradigm of IPF pathogenesis, in which recurrent injury to the alveolar epithelium is believed to drive aberrant wound healing responses, resulting in fibrosis rather than repair. Here we discuss drugs in recently completed or currently ongoing phase II and III IPF clinical trials in the context of their putative mechanisms of action and the aberrant repair processes they are believed to target: innate immune activation and polarization, fibroblast accumulation and myofibroblast differentiation, or extracellular matrix deposition and stiffening. Placed in this context, the positive results of recently completed trials of pirfenidone and nintedanib, and results that will come from ongoing trials of other agents, should provide valuable insights into the still-enigmatic pathogenesis of this disease, in addition to providing benefits to patients with IPF. Twit Text FOAVip New therapeutic targets in idiopathic pulmonary fibrosis Aiming to rein in runaway wound-healing responses ????Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=25090037 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25090037 #FOAvip English Wikipedia <ref>{{Cite pmid|25090037 }}</ref> New therapeutic targets in idiopathic pulmonary fibrosis Aiming to rein in runaway wound-healing responses #MMPMID25090037 Ahluwalia N ; Shea BS ; Tager AM Am J Respir Crit Care Med 2014[Oct]; 190 (8 ): 867-78 PMID25090037 show ga Idiopathic pulmonary fibrosis (IPF) is a devastating disease, with a median survival as short as 3 years from the time of diagnosis and no pharmacological therapies yet approved by the U.S. Food and Drug Administration. To address the great unmet need for effective IPF therapy, a number of new drugs have recently been, or are now being, evaluated in clinical trials. The rationales for most of these therapeutic candidates are based on the current paradigm of IPF pathogenesis, in which recurrent injury to the alveolar epithelium is believed to drive aberrant wound healing responses, resulting in fibrosis rather than repair. Here we discuss drugs in recently completed or currently ongoing phase II and III IPF clinical trials in the context of their putative mechanisms of action and the aberrant repair processes they are believed to target: innate immune activation and polarization, fibroblast accumulation and myofibroblast differentiation, or extracellular matrix deposition and stiffening. Placed in this context, the positive results of recently completed trials of pirfenidone and nintedanib, and results that will come from ongoing trials of other agents, should provide valuable insights into the still-enigmatic pathogenesis of this disease, in addition to providing benefits to patients with IPF. |Anti-Inflammatory Agents, Non-Steroidal/pharmacology/*therapeutic use [MESH] |Antioxidants/pharmacology/therapeutic use [MESH] |Clinical Trials, Phase II as Topic [MESH] |Clinical Trials, Phase III as Topic [MESH] |Enzyme Inhibitors/pharmacology/*therapeutic use [MESH] |Humans [MESH] |Idiopathic Pulmonary Fibrosis/*drug therapy/etiology/physiopathology [MESH] |Immunosuppressive Agents/pharmacology/therapeutic use [MESH] |Indoles/pharmacology/*therapeutic use [MESH] |Pyridones/pharmacology/*therapeutic use [MESH]New therapeutic targets in idiopathic pulmonary fibrosis Aiming to re(epmc).pdf DeepDyve Pubget Overpricing