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10.1242/dev.117200 http://scihub22266oqcxt.onion/10.1242/dev.117200 C4299273!4299273!25395457     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Development 2014 ; 141 (24): 4751-62 Nephropedia Template TP {{tp|p=25395457|t=2014. Epithelial ?1 integrin is required for lung branching morphogenesis and alveolarization |pdf=|usr=}}{{25395457}} gab.com Text Epithelial 1 integrin is required for lung branching morphogenesis and alveolarization JO: Development http://www.kidney.de/pget.php?&tw=1&pmid=25395457 #FOAvip Integrin-dependent interactions between cells and extracellular matrix regulate lung development; however, specific roles for ?1-containing integrins in individual cell types, including epithelial cells, remain incompletely understood. In this study, the functional importance of ?1 integrin in lung epithelium during mouse lung development was investigated by deleting the integrin from E10.5 onwards using surfactant protein C promoter-driven Cre. These mutant mice appeared normal at birth but failed to gain weight appropriately and died by 4?months of age with severe hypoxemia. Defects in airway branching morphogenesis in association with impaired epithelial cell adhesion and migration, as well as alveolarization defects and persistent macrophage-mediated inflammation were identified. Using an inducible system to delete ?1 integrin after completion of airway branching, we showed that alveolarization defects, characterized by disrupted secondary septation, abnormal alveolar epithelial cell differentiation, excessive collagen I and elastin deposition, and hypercellularity of the mesenchyme occurred independently of airway branching defects. By depleting macrophages using liposomal clodronate, we found that alveolarization defects were secondary to persistent alveolar inflammation. ?1 integrin-deficient alveolar epithelial cells produced excessive monocyte chemoattractant protein 1 and reactive oxygen species, suggesting a direct role for ?1 integrin in regulating alveolar homeostasis. Taken together, these studies define distinct functions of epithelial ?1 integrin during both early and late lung development that affect airway branching morphogenesis, epithelial cell differentiation, alveolar septation and regulation of alveolar homeostasis. Twit Text FOAVip Epithelial 1 integrin is required for lung branching morphogenesis and alveolarization ????Development http://www.kidney.de/pget.php?&tw=1&pmid=25395457 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25395457 #FOAvip English Wikipedia <ref>{{Cite pmid|25395457}}</ref> Epithelial ?1 integrin is required for lung branching morphogenesis and alveolarization #MMPMID25395457 Plosa EJ; Young LR; Gulleman PM; Polosukhin VV; Zaynagetdinov R; Benjamin JT; Im AM; van der Meer R; Gleaves LA; Bulus N; Han W; Prince LS; Blackwell TS; Zent R Development 2014[Dec]; 141 (24): 4751-62 PMID25395457show ga Integrin-dependent interactions between cells and extracellular matrix regulate lung development; however, specific roles for ?1-containing integrins in individual cell types, including epithelial cells, remain incompletely understood. In this study, the functional importance of ?1 integrin in lung epithelium during mouse lung development was investigated by deleting the integrin from E10.5 onwards using surfactant protein C promoter-driven Cre. These mutant mice appeared normal at birth but failed to gain weight appropriately and died by 4?months of age with severe hypoxemia. Defects in airway branching morphogenesis in association with impaired epithelial cell adhesion and migration, as well as alveolarization defects and persistent macrophage-mediated inflammation were identified. Using an inducible system to delete ?1 integrin after completion of airway branching, we showed that alveolarization defects, characterized by disrupted secondary septation, abnormal alveolar epithelial cell differentiation, excessive collagen I and elastin deposition, and hypercellularity of the mesenchyme occurred independently of airway branching defects. By depleting macrophages using liposomal clodronate, we found that alveolarization defects were secondary to persistent alveolar inflammation. ?1 integrin-deficient alveolar epithelial cells produced excessive monocyte chemoattractant protein 1 and reactive oxygen species, suggesting a direct role for ?1 integrin in regulating alveolar homeostasis. Taken together, these studies define distinct functions of epithelial ?1 integrin during both early and late lung development that affect airway branching morphogenesis, epithelial cell differentiation, alveolar septation and regulation of alveolar homeostasis. äEpithelial ?1 integrin is required for lung branching morphogenesis an(epmc).pdf DeepDyve Pubget Overpricing