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10.1073/pnas.1423011112 http://scihub22266oqcxt.onion/10.1073/pnas.1423011112 C4299239!4299239!25550515     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (2): 494-9 Nephropedia Template TP {{tp|p=25550515|t=2015. Intracellular osteopontin regulates homeostasis and function of natural killer cells |pdf=|usr=}}{{25550515}} gab.com Text Intracellular osteopontin regulates homeostasis and function of natural killer cells JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25550515 #FOAvip Maintenance of a pool of natural killer (NK) cells with optimal immune function is crucial for host defense against pathogens or cancerous tumor formation. Here we identify intracellular osteopontin (OPN-i) as an essential molecular component responsible for maintenance of functional NK cell expansion. Absence of OPN-i results in failure to maintain normal NK cellularity and increased cell death following stimulation by cytokine interleukin-15. OPN-deficient NK cells fail to successfully navigate the contraction phase of the immune response, resulting in impaired expansion of long-lived NK cells and defective responses to viral infection and tumor cells. Insight into the contribution of OPN-i to NK cell responses may provide the basis for improved approaches to immunotherapy for infectious disease and cancer. Twit Text FOAVip Intracellular osteopontin regulates homeostasis and function of natural killer cells ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25550515 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25550515 #FOAvip English Wikipedia <ref>{{Cite pmid|25550515}}</ref> Intracellular osteopontin regulates homeostasis and function of natural killer cells #MMPMID25550515 Leavenworth JW; Verbinnen B; Wang Q; Shen E; Cantor H Proc Natl Acad Sci U S A 2015[Jan]; 112 (2): 494-9 PMID25550515show ga Maintenance of a pool of natural killer (NK) cells with optimal immune function is crucial for host defense against pathogens or cancerous tumor formation. Here we identify intracellular osteopontin (OPN-i) as an essential molecular component responsible for maintenance of functional NK cell expansion. Absence of OPN-i results in failure to maintain normal NK cellularity and increased cell death following stimulation by cytokine interleukin-15. OPN-deficient NK cells fail to successfully navigate the contraction phase of the immune response, resulting in impaired expansion of long-lived NK cells and defective responses to viral infection and tumor cells. Insight into the contribution of OPN-i to NK cell responses may provide the basis for improved approaches to immunotherapy for infectious disease and cancer. äIntracellular osteopontin regulates homeostasis and function of natura(epmc).pdf DeepDyve Pubget Overpricing