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10.1073/pnas.1404167111 http://scihub22266oqcxt.onion/10.1073/pnas.1404167111 C4299227!4299227!25453080     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25453080&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (2): 458-63 Nephropedia Template TP {{tp|p=25453080|t=2015. Hominids adapted to metabolize ethanol long before human-directed fermentation |pdf=|usr=}}{{25453080}} gab.com Text Hominids adapted to metabolize ethanol long before human-directed fermentation JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25453080 #FOAvip Many modern human diseases are attributed to incompatibility between our current environment and the environment for which our genome is adapted. It is unclear whether this model applies to alcoholism. We investigated this possibility by studying alcohol dehydrogenase class IV (ADH4), the first enzyme exposed to ethanol in the digestive tract that is capable of metabolizing ethanol. We resurrected ancestral ADH4 enzymes from various points in the ?70 million y of primate evolution and identified a single mutation occurring ?10 million y ago that endowed our ancestors with a markedly enhanced ability to metabolize ethanol. This change occurred approximately when our ancestors adopted a terrestrial lifestyle and may have been advantageous to primates living where highly fermented fruit is more likely. Twit Text FOAVip Hominids adapted to metabolize ethanol long before human-directed fermentation ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25453080 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25453080 #FOAvip English Wikipedia <ref>{{Cite pmid|25453080}}</ref> Hominids adapted to metabolize ethanol long before human-directed fermentation #MMPMID25453080 Carrigan MA; Uryasev O; Frye CB; Eckman BL; Myers CR; Hurley TD; Benner SA Proc Natl Acad Sci U S A 2015[Jan]; 112 (2): 458-63 PMID25453080show ga Many modern human diseases are attributed to incompatibility between our current environment and the environment for which our genome is adapted. It is unclear whether this model applies to alcoholism. We investigated this possibility by studying alcohol dehydrogenase class IV (ADH4), the first enzyme exposed to ethanol in the digestive tract that is capable of metabolizing ethanol. We resurrected ancestral ADH4 enzymes from various points in the ?70 million y of primate evolution and identified a single mutation occurring ?10 million y ago that endowed our ancestors with a markedly enhanced ability to metabolize ethanol. This change occurred approximately when our ancestors adopted a terrestrial lifestyle and may have been advantageous to primates living where highly fermented fruit is more likely. äHominids adapted to metabolize ethanol long before human-directed ferm(epmc).pdf DeepDyve Pubget Overpricing