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10.1073/pnas.1417508112 http://scihub22266oqcxt.onion/10.1073/pnas.1417508112 C4299224!4299224!25548184     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (2): 542-7 Nephropedia Template TP {{tp|p=25548184|t=2015. A red meat-derived glycan promotes inflammation and cancer progression |pdf=|usr=}}{{25548184}} gab.com Text A red meat-derived glycan promotes inflammation and cancer progression JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25548184 #FOAvip We present an unusual mechanism for the well-known association between red meat consumption and carcinoma risk involving the nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc). We first evaluate the Neu5Gc content of various foods to show that red meats are particularly rich in orally bioavailable Neu5Gc and then investigate human-like Neu5Gc-deficient mice fed this form of Neu5Gc. When such mice were challenged with anti-Neu5Gc antibodies, they developed evidence of systemic inflammation. Long-term exposure to this combination resulted in a significantly higher incidence of carcinomas (five-fold increase) and an association with Neu5Gc accumulation in the tumors. Similar mechanisms may contribute to the association of red meat consumption with other diseases, such as atherosclerosis and type 2 diabetes, which are also exacerbated by inflammation. Twit Text FOAVip A red meat-derived glycan promotes inflammation and cancer progression ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25548184 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25548184 #FOAvip English Wikipedia <ref>{{Cite pmid|25548184}}</ref> A red meat-derived glycan promotes inflammation and cancer progression #MMPMID25548184 Samraj AN; Pearce OMT; Läubli H; Crittenden AN; Bergfeld AK; Banda K; Gregg CJ; Bingman AE; Secrest P; Diaz SL; Varki NM; Varki A Proc Natl Acad Sci U S A 2015[Jan]; 112 (2): 542-7 PMID25548184show ga We present an unusual mechanism for the well-known association between red meat consumption and carcinoma risk involving the nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc). We first evaluate the Neu5Gc content of various foods to show that red meats are particularly rich in orally bioavailable Neu5Gc and then investigate human-like Neu5Gc-deficient mice fed this form of Neu5Gc. When such mice were challenged with anti-Neu5Gc antibodies, they developed evidence of systemic inflammation. Long-term exposure to this combination resulted in a significantly higher incidence of carcinomas (five-fold increase) and an association with Neu5Gc accumulation in the tumors. Similar mechanisms may contribute to the association of red meat consumption with other diseases, such as atherosclerosis and type 2 diabetes, which are also exacerbated by inflammation. äA red meat-derived glycan promotes inflammation and cancer progression(epmc).pdf DeepDyve Pubget Overpricing