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10.1513/AnnalsATS.201403-108AW

http://scihub22266oqcxt.onion/10.1513/AnnalsATS.201403-108AW
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C4298968!4298968!25525731
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suck abstract from ncbi


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pmid25525731      Ann+Am+Thorac+Soc 2014 ; 11 (Suppl 5): S271-6
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  • The Regulation of Pulmonary Inflammation by the Hypoxia-Inducible Factor?Hydroxylase Oxygen-Sensing Pathway #MMPMID25525731
  • Whyte MKB; Walmsley SR
  • Ann Am Thorac Soc 2014[Dec]; 11 (Suppl 5): S271-6 PMID25525731show ga
  • Although the hypoxia-inducible factor (HIF)?hydroxylase oxygen-sensing pathway has been extensively reviewed in the context of cellular responses to hypoxia and cancer biology, its importance in regulating innate immune biology is less well described. In this review, we focus on the role of the HIF-hydroxylase pathway in regulating myeloid cell responses and its relevance to inflammatory lung disease. The more specific roles of individual HIF/ prolyl hydroxylase pathway members in vivo are discussed in the context of lineage-specific rodent models of inflammation, with final reference made to the therapeutic challenges of targeting the HIF/hydroxylase pathway in immune cells.
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