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Metabolomics in pediatric nephrology: Emerging concepts #MMPMID25027575
Hanna MH; Brophy PD
Pediatr Nephrol 2015[Jun]; 30 (6): 881-7 PMID25027575show ga
Metabolomics, the latest of the ?omics? sciences, refers to the systematic study of metabolites and their changes in biological samples due to physiological stimuli and/or genetic modification. Because metabolites represent the downstream expression of genome, transcriptome and proteome, they can closely reflect the phenotype of an organism at a specific time. As an emerging field in analytical biochemistry; metabolomics has the potential to play a major role for monitoring real-time kidney function and detecting adverse renal events. Additionally, small molecule metabolites can provide mechanistic insights for novel biomarkers of kidney diseases, given the limitations of the current traditional markers.The clinical utility of metabolomics in the field of pediatric nephrology includes biomarker discovery, defining as yet unrecognized biologic therapeutic targets, linking of metabolites to relevant standard indices and clinical outcomes, and providing a window of opportunity to investigate the intricacies of environment/genetic interplay in specific disease states.