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10.1128/MCB.01187-14 http://scihub22266oqcxt.onion/10.1128/MCB.01187-14 C4295374!4295374 !25332234     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25332234 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25332234 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell+Biol 2015 ; 35 (1 ): 153-66 Nephropedia Template TP {{tp|p=25332234 |t=2015. mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion |pdf=|usr=}}{{25332234 }} gab.com Text mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion JO: Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25332234 #FOAvip Plasma cells (PCs) are responsible for the secretion of antibodies. The development of fully functional PCs relies on the activation of the inositol-requiring enzyme 1/X-box binding protein 1 (IRE1/XBP-1) arm of the unfolded protein response (UPR). XBP-1-deficient PCs secrete antibodies poorly and exhibit distensions of the endoplasmic reticulum (ER). The kinase mammalian target of rapamycin (mTOR) promotes anabolic activities and is negatively regulated by the tuberous sclerosis complex (TSC). Deletion of TSC1 renders mTOR hyperactive. To explore the relationship between mTOR and the UPR in PC development and function, mice with conditional deletions of XBP-1 and/or TSC1 in their B cell lineage were generated. Deletion of TSC1 enhanced Ig synthesis and promoted differentiation into PCs independently of XBP-1, as evidenced by comparison of TSC1/XBP-1 double-knockout (DKO) PCs to XBP-1 knockout (KO) PCs. The typical morphological abnormalities of the ER in XBP-1 KO PCs were alleviated in the DKO PCs. Expression profiling identified the glycoprotein Ly6C as an mTOR target. Ly6C expression contributed to the enhanced Ig secretion from DKO PCs. Our data reveal a functional overlap between mTOR and the UPR in promoting PC development. In addition to the classical mTOR role in promoting protein synthesis, the mechanism entails transcription regulation of accessory molecules, such as Ly6C. Twit Text FOAVip mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion ????Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25332234 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25332234 #FOAvip English Wikipedia <ref>{{Cite pmid|25332234 }}</ref> mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion #MMPMID25332234 Benhamron S ; Pattanayak SP ; Berger M ; Tirosh B Mol Cell Biol 2015[Jan]; 35 (1 ): 153-66 PMID25332234 show ga Plasma cells (PCs) are responsible for the secretion of antibodies. The development of fully functional PCs relies on the activation of the inositol-requiring enzyme 1/X-box binding protein 1 (IRE1/XBP-1) arm of the unfolded protein response (UPR). XBP-1-deficient PCs secrete antibodies poorly and exhibit distensions of the endoplasmic reticulum (ER). The kinase mammalian target of rapamycin (mTOR) promotes anabolic activities and is negatively regulated by the tuberous sclerosis complex (TSC). Deletion of TSC1 renders mTOR hyperactive. To explore the relationship between mTOR and the UPR in PC development and function, mice with conditional deletions of XBP-1 and/or TSC1 in their B cell lineage were generated. Deletion of TSC1 enhanced Ig synthesis and promoted differentiation into PCs independently of XBP-1, as evidenced by comparison of TSC1/XBP-1 double-knockout (DKO) PCs to XBP-1 knockout (KO) PCs. The typical morphological abnormalities of the ER in XBP-1 KO PCs were alleviated in the DKO PCs. Expression profiling identified the glycoprotein Ly6C as an mTOR target. Ly6C expression contributed to the enhanced Ig secretion from DKO PCs. Our data reveal a functional overlap between mTOR and the UPR in promoting PC development. In addition to the classical mTOR role in promoting protein synthesis, the mechanism entails transcription regulation of accessory molecules, such as Ly6C. |Animals [MESH] |Antigens, CD19/metabolism [MESH] |Antigens, Ly/metabolism [MESH] |B-Lymphocytes/cytology [MESH] |Bone Marrow Cells/cytology [MESH] |Cell Differentiation [MESH] |DNA-Binding Proteins/*metabolism [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Immunoglobulin A/metabolism [MESH] |Immunoglobulins/blood/*metabolism [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Knockout [MESH] |Microscopy, Electron, Transmission [MESH] |Phosphorylation [MESH] |Regulatory Factor X Transcription Factors [MESH] |TOR Serine-Threonine Kinases/*metabolism [MESH] |Transcription Factors/*metabolism [MESH] |Tuberous Sclerosis Complex 1 Protein [MESH] |Tumor Suppressor Proteins/metabolism [MESH] |Unfolded Protein Response [MESH]mTOR activation promotes plasma cell differentiation and bypasses XBP-(epmc).pdf DeepDyve Pubget Overpricing