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10.1111/bph.12838 http://scihub22266oqcxt.onion/10.1111/bph.12838 C4294039!4294039 !25041185     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25041185 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Br+J+Pharmacol 2014 ; 171 (23 ): 5265-79 Nephropedia Template TP {{tp|p=25041185 |t=2014. Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1 |pdf=|usr=}}{{25041185 }} gab.com Text Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1 JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25041185 #FOAvip BACKGROUND AND PURPOSE: Celastrol, a triterpene from plants, has been used in traditional oriental medicine to treat various diseases. Here, we investigated the cardioprotective effects of celastrol against ischaemia. EXPERIMENTAL APPROACH: Protective pathways induced by celastrol were investigated in hypoxic cultures of H9c2 rat cardiomyoblasts and in a rat model of myocardial infarction, assessed with echocardiographic and histological analysis. KEY RESULTS: In H9c2 cells, celastrol triggered reactive oxygen species (ROS) formation within minutes, induced nuclear translocation of the transcription factor heat shock factor 1 (HSF1) resulting in a heat shock response (HSR) leading to increased expression of heat shock proteins (HSPs). ROS scavenger N-acetylcysteine reduced expression of HSP70 and HSP32 (haeme oxygenase-1, HO-1). Celastrol improved H9c2 survival under hypoxic stress, and functional analysis revealed HSF1 and HO-1 as key effectors of the HSR, induced by celastrol, in promoting cytoprotection. In the rat ischaemic myocardium, celastrol treatment improved cardiac function and reduced adverse left ventricular remodelling at 14 days. Celastrol triggered expression of cardioprotective HO-1 and inhibited fibrosis and infarct size. In the peri-infarct area, celastrol reduced myofibroblast and macrophage infiltration, while attenuating up-regulation of TGF-? and collagen genes. CONCLUSIONS AND IMPLICATIONS: Celastrol treatment induced an HSR through activation of HSF1 with up-regulation of HO-1 as the key effector, promoting cardiomyocyte survival, reduction of injury and adverse remodelling with preservation of cardiac function. Celastrol may represent a novel potent pharmacological cardioprotective agent mimicking ischaemic conditioning that could have a valuable impact in the treatment of myocardial infarction. Twit Text FOAVip Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1 ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25041185 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25041185 #FOAvip English Wikipedia <ref>{{Cite pmid|25041185 }}</ref> Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1 #MMPMID25041185 Der Sarkissian S ; Cailhier JF ; Borie M ; Stevens LM ; Gaboury L ; Mansour S ; Hamet P ; Noiseux N Br J Pharmacol 2014[Dec]; 171 (23 ): 5265-79 PMID25041185 show ga BACKGROUND AND PURPOSE: Celastrol, a triterpene from plants, has been used in traditional oriental medicine to treat various diseases. Here, we investigated the cardioprotective effects of celastrol against ischaemia. EXPERIMENTAL APPROACH: Protective pathways induced by celastrol were investigated in hypoxic cultures of H9c2 rat cardiomyoblasts and in a rat model of myocardial infarction, assessed with echocardiographic and histological analysis. KEY RESULTS: In H9c2 cells, celastrol triggered reactive oxygen species (ROS) formation within minutes, induced nuclear translocation of the transcription factor heat shock factor 1 (HSF1) resulting in a heat shock response (HSR) leading to increased expression of heat shock proteins (HSPs). ROS scavenger N-acetylcysteine reduced expression of HSP70 and HSP32 (haeme oxygenase-1, HO-1). Celastrol improved H9c2 survival under hypoxic stress, and functional analysis revealed HSF1 and HO-1 as key effectors of the HSR, induced by celastrol, in promoting cytoprotection. In the rat ischaemic myocardium, celastrol treatment improved cardiac function and reduced adverse left ventricular remodelling at 14 days. Celastrol triggered expression of cardioprotective HO-1 and inhibited fibrosis and infarct size. In the peri-infarct area, celastrol reduced myofibroblast and macrophage infiltration, while attenuating up-regulation of TGF-? and collagen genes. CONCLUSIONS AND IMPLICATIONS: Celastrol treatment induced an HSR through activation of HSF1 with up-regulation of HO-1 as the key effector, promoting cardiomyocyte survival, reduction of injury and adverse remodelling with preservation of cardiac function. Celastrol may represent a novel potent pharmacological cardioprotective agent mimicking ischaemic conditioning that could have a valuable impact in the treatment of myocardial infarction. |Animals [MESH] |Cardiotonic Agents/pharmacology/*therapeutic use [MESH] |Cell Line [MESH] |Cell Survival/drug effects [MESH] |DNA-Binding Proteins/metabolism [MESH] |Female [MESH] |HSP70 Heat-Shock Proteins/metabolism [MESH] |Heat Shock Transcription Factors [MESH] |Heat-Shock Response/drug effects [MESH] |Heme Oxygenase (Decyclizing)/biosynthesis [MESH] |Hypoxia/metabolism [MESH] |MAP Kinase Signaling System/drug effects [MESH] |Myocardial Ischemia/*drug therapy/metabolism/pathology/physiopathology [MESH] |Myocardium/pathology [MESH] |Oncogene Protein v-akt/metabolism [MESH] |Pentacyclic Triterpenes [MESH] |Phosphatidylinositol 3-Kinases/metabolism [MESH] |Rats, Sprague-Dawley [MESH] |Reactive Oxygen Species/metabolism [MESH] |Transcription Factors/metabolism [MESH] |Triterpenes/pharmacology/*therapeutic use [MESH]Celastrol protects ischaemic myocardium through a heat shock response (epmc).pdf DeepDyve Pubget Overpricing