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10.1523/JNEUROSCI.2923-14.2015 http://scihub22266oqcxt.onion/10.1523/JNEUROSCI.2923-14.2015 C4293409!4293409!25589748     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neurosci 2015 ; 35 (2): 527-43 Nephropedia Template TP {{tp|p=25589748|t=2015. Hypoxia Silences Retrotrapezoid Nucleus Respiratory Chemoreceptors via Alkalosis |pdf=|usr=}}{{25589748}} gab.com Text Hypoxia Silences Retrotrapezoid Nucleus Respiratory Chemoreceptors via Alkalosis JO: J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25589748 #FOAvip In conscious mammals, hypoxia or hypercapnia stimulates breathing while theoretically exerting opposite effects on central respiratory chemoreceptors (CRCs). We tested this theory by examining how hypoxia and hypercapnia change the activity of the retrotrapezoid nucleus (RTN), a putative CRC and chemoreflex integrator. Archaerhodopsin-(Arch)-transduced RTN neurons were reversibly silenced by light in anesthetized rats. We bilaterally transduced RTN and nearby C1 neurons with Arch (PRSx8-ArchT-EYFP-LVV) and measured the cardiorespiratory consequences of Arch activation (10 s) in conscious rats during normoxia, hypoxia, or hyperoxia. RTN photoinhibition reduced breathing equally during non-REM sleep and quiet wake. Compared with normoxia, the breathing frequency reduction (?fR) was larger in hyperoxia (65% FiO2), smaller in 15% FiO2, and absent in 12% FiO2. Tidal volume changes (?VT) followed the same trend. The effect of hypoxia on ?fR was not arousal-dependent but was reversed by reacidifying the blood (acetazolamide; 3% FiCO2). ?fR was highly correlated with arterial pH up to arterial pH (pHa) 7.5 with no frequency inhibition occurring above pHa 7.53. Blood pressure was minimally reduced suggesting that C1 neurons were very modestly inhibited. In conclusion, RTN neurons regulate eupneic breathing about equally during both sleep and wake. RTN neurons are the first putative CRCs demonstrably silenced by hypocapnic hypoxia in conscious mammals. RTN neurons are silent above pHa 7.5 and increasingly active below this value. During hyperoxia, RTN activation maintains breathing despite the inactivity of the carotid bodies. Finally, during hypocapnic hypoxia, carotid body stimulation increases breathing frequency via pathways that bypass RTN. Twit Text FOAVip Hypoxia Silences Retrotrapezoid Nucleus Respiratory Chemoreceptors via Alkalosis ????J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25589748 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25589748 #FOAvip English Wikipedia <ref>{{Cite pmid|25589748}}</ref> Hypoxia Silences Retrotrapezoid Nucleus Respiratory Chemoreceptors via Alkalosis #MMPMID25589748 Basting TM; Burke PG; Kanbar R; Viar KE; Stornetta DS; Stornetta RL; Guyenet PG J Neurosci 2015[Jan]; 35 (2): 527-43 PMID25589748show ga In conscious mammals, hypoxia or hypercapnia stimulates breathing while theoretically exerting opposite effects on central respiratory chemoreceptors (CRCs). We tested this theory by examining how hypoxia and hypercapnia change the activity of the retrotrapezoid nucleus (RTN), a putative CRC and chemoreflex integrator. Archaerhodopsin-(Arch)-transduced RTN neurons were reversibly silenced by light in anesthetized rats. We bilaterally transduced RTN and nearby C1 neurons with Arch (PRSx8-ArchT-EYFP-LVV) and measured the cardiorespiratory consequences of Arch activation (10 s) in conscious rats during normoxia, hypoxia, or hyperoxia. RTN photoinhibition reduced breathing equally during non-REM sleep and quiet wake. Compared with normoxia, the breathing frequency reduction (?fR) was larger in hyperoxia (65% FiO2), smaller in 15% FiO2, and absent in 12% FiO2. Tidal volume changes (?VT) followed the same trend. The effect of hypoxia on ?fR was not arousal-dependent but was reversed by reacidifying the blood (acetazolamide; 3% FiCO2). ?fR was highly correlated with arterial pH up to arterial pH (pHa) 7.5 with no frequency inhibition occurring above pHa 7.53. Blood pressure was minimally reduced suggesting that C1 neurons were very modestly inhibited. In conclusion, RTN neurons regulate eupneic breathing about equally during both sleep and wake. RTN neurons are the first putative CRCs demonstrably silenced by hypocapnic hypoxia in conscious mammals. RTN neurons are silent above pHa 7.5 and increasingly active below this value. During hyperoxia, RTN activation maintains breathing despite the inactivity of the carotid bodies. Finally, during hypocapnic hypoxia, carotid body stimulation increases breathing frequency via pathways that bypass RTN. äHypoxia Silences Retrotrapezoid Nucleus Respiratory Chemoreceptors via(epmc).pdf DeepDyve Pubget Overpricing