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10.1523/JNEUROSCI.3742-14.2015 http://scihub22266oqcxt.onion/10.1523/JNEUROSCI.3742-14.2015 C4293408!4293408!25589747     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neurosci 2015 ; 35 (2): 518-26 Nephropedia Template TP {{tp|p=25589747|t=2015. Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System |pdf=|usr=}}{{25589747}} gab.com Text Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System JO: J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25589747 #FOAvip The nonspecific and variable presentation of traumatic brain injury (TBI) has motivated an intense search for blood-based biomarkers that can objectively predict the severity of injury. However, it is not known how cytosolic proteins released from traumatized brain tissue reach the peripheral blood. Here we show in a murine TBI model that CSF movement through the recently characterized glymphatic pathway transports biomarkers to blood via the cervical lymphatics. Clinically relevant manipulation of glymphatic activity, including sleep deprivation and cisternotomy, suppressed or eliminated TBI-induced increases in serum S100?, GFAP, and neuron specific enolase. We conclude that routine TBI patient management may limit the clinical utility of blood-based biomarkers because their brain-to-blood transport depends on glymphatic activity. Twit Text FOAVip Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System ????J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25589747 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25589747 #FOAvip English Wikipedia <ref>{{Cite pmid|25589747}}</ref> Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System #MMPMID25589747 Plog BA; Dashnaw ML; Hitomi E; Peng W; Liao Y; Lou N; Deane R; Nedergaard M J Neurosci 2015[Jan]; 35 (2): 518-26 PMID25589747show ga The nonspecific and variable presentation of traumatic brain injury (TBI) has motivated an intense search for blood-based biomarkers that can objectively predict the severity of injury. However, it is not known how cytosolic proteins released from traumatized brain tissue reach the peripheral blood. Here we show in a murine TBI model that CSF movement through the recently characterized glymphatic pathway transports biomarkers to blood via the cervical lymphatics. Clinically relevant manipulation of glymphatic activity, including sleep deprivation and cisternotomy, suppressed or eliminated TBI-induced increases in serum S100?, GFAP, and neuron specific enolase. We conclude that routine TBI patient management may limit the clinical utility of blood-based biomarkers because their brain-to-blood transport depends on glymphatic activity. äBiomarkers of Traumatic Injury Are Transported from Brain to Blood via(epmc).pdf DeepDyve Pubget Overpricing