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10.1158/0008-5472.CAN-14-2329 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-2329 C4292868!4292868!25326492     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2014 ; 74 (24): 7181-4 Nephropedia Template TP {{tp|p=25326492|t=2014. Unique Molecular Landscapes in Cancer: Implications for Individualized, Curated Drug Combinations |pdf=|usr=}}{{25326492}} gab.com Text Unique Molecular Landscapes in Cancer: Implications for Individualized, Curated Drug Combinations JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25326492 #FOAvip With increasing lysophisticated technologies in molecular biology and ?omic? platforms to analyze patients? tumors, more molecular diversity and complexity in cancer are being observed. Recently, we noted unique genomic profiles in a group of patients with metastatic breast cancer based on an analysis with next generation sequencing (NGS); amongst 57 consecutive patients, no two had the same molecular portfolio (1). Applied genomics therefore appears to represent a disruptive innovation in that it unveils a heterogeneity to metastatic cancer that may be ill suited to canonical clinical trials and practice paradigms. Upon recognizing that patients have unique tumor landscapes, it is possible that there may be a ?mismatch? between our traditional clinical trials system that selects patients based on common characteristics in order to evaluate a drug (drug-centric approach), and optimal treatment based on curated, individualized drug combinations for each patient (patient-centric approach). Twit Text FOAVip Unique Molecular Landscapes in Cancer: Implications for Individualized, Curated Drug Combinations ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25326492 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25326492 #FOAvip English Wikipedia <ref>{{Cite pmid|25326492}}</ref> Unique Molecular Landscapes in Cancer: Implications for Individualized, Curated Drug Combinations #MMPMID25326492 Wheler J; Lee JJ; Kurzrock R Cancer Res 2014[Dec]; 74 (24): 7181-4 PMID25326492show ga With increasing lysophisticated technologies in molecular biology and ?omic? platforms to analyze patients? tumors, more molecular diversity and complexity in cancer are being observed. Recently, we noted unique genomic profiles in a group of patients with metastatic breast cancer based on an analysis with next generation sequencing (NGS); amongst 57 consecutive patients, no two had the same molecular portfolio (1). Applied genomics therefore appears to represent a disruptive innovation in that it unveils a heterogeneity to metastatic cancer that may be ill suited to canonical clinical trials and practice paradigms. Upon recognizing that patients have unique tumor landscapes, it is possible that there may be a ?mismatch? between our traditional clinical trials system that selects patients based on common characteristics in order to evaluate a drug (drug-centric approach), and optimal treatment based on curated, individualized drug combinations for each patient (patient-centric approach). äUnique Molecular Landscapes in Cancer: Implications for Individualized(epmc).pdf DeepDyve Pubget Overpricing