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10.4161/21624011.2014.967146

http://scihub22266oqcxt.onion/10.4161/21624011.2014.967146
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suck abstract from ncbi


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pmid25941596      Oncoimmunology 2014 ; 3 (11): ä
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  • Lymphocyte activation gene-3 (LAG-3, CD223) in plasmacytoid dendritic cells (pDCs): a molecular target for the restoration of active antitumor immunity #MMPMID25941596
  • Castelli C; Triebel F; Rivoltini L; Camisaschi C
  • Oncoimmunology 2014[]; 3 (11): ä PMID25941596show ga
  • We have recently reported that lymphocyte activation gene-3 (LAG-3,CD223) mediates the alternative, IFN?-deficient activation of plasmacytoid dendritic cells (pDCs) at tumor sites. Our findings define a novel tumor-driven strategy that promotes immunosuppression by pDCs, and we have provided more detailed information regarding the immunomodulatory role of of LAG-3. The translational relevance of our results for the treatment of tumors and autoimmune diseases is discussed herein.
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